Freelance Journalist, Berlin, Germany.
Biomed J. 2024 Aug;47(4):100773. doi: 10.1016/j.bj.2024.100773. Epub 2024 Jul 23.
This issue of the Biomedical Journal highlights major advancements in drug delivery, including aptamer-functionalized liposomes and nanozymes. A new biomarker combination shows promise for improved diagnosis of idiopathic pulmonary fibrosis. Mesenchymal stem cells are suggested to mitigate inflammation in systemic lupus erythematosus, and a potential positive feedback loop driven by a prevalent mRNA modification is suggested to enhance NSCLC progression. Additional articles explore a pathological impact on autophagy leading to muscle dysfunction, the benefits of integrating an orphan drug with standard therapy for glioblastoma patients, and the influence of transcriptional super-enhancers in early-stage esophageal squamous cell carcinoma. Finally, this issue provides insights into the roles of different Blastocystis subtypes, and the use of laser light for treating infantile hemangioma.
本期《生物医学期刊》重点介绍了药物输送方面的重大进展,包括适体功能化脂质体和纳米酶。一种新的生物标志物组合有望改善特发性肺纤维化的诊断。间充质干细胞被认为可以减轻系统性红斑狼疮的炎症,并且一个由常见的 mRNA 修饰驱动的潜在正反馈循环被认为可以增强非小细胞肺癌的进展。其他文章探讨了导致肌肉功能障碍的自噬的病理影响,将孤儿药物与胶质母细胞瘤患者的标准疗法相结合的益处,以及转录超级增强子在早期食管鳞状细胞癌中的影响。最后,本期期刊还介绍了不同 Blastocystis 亚型的作用,以及激光治疗婴儿血管瘤的应用。