Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany.
Department of Paediatric Hematology, Oncology, and Immunology, University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory and University of Heidelberg, Heidelberg, Germany.
Trends Immunol. 2024 Aug;45(8):625-638. doi: 10.1016/j.it.2024.06.006. Epub 2024 Jul 24.
Myeloid cells that populate all human organs and blood are a versatile class of innate immune cells. They are crucial for sensing and regulating processes as diverse as tissue homeostasis and inflammation and are frequently characterized by their roles in either regulating or promoting inflammation. Recent studies in cultured cells and mouse models highlight the role of iron in skewing the functional properties of myeloid cells in tissue damage and repair. Here, we review certain emerging concepts on how iron influences and determines myeloid cell polarization in the context of its uptake, storage, and metabolism, including in conditions such as multiple sclerosis (MS), sickle cell disease, and tumors.
存在于所有人体器官和血液中的髓系细胞是一类多功能的先天免疫细胞。它们对于感知和调节组织稳态和炎症等多样化的过程至关重要，并且通常以其在调节或促进炎症中的作用为特征。最近在培养细胞和小鼠模型中的研究强调了铁在塑造组织损伤和修复过程中髓样细胞功能特性方面的作用。在这里，我们回顾了某些新兴概念，即铁如何影响和决定髓样细胞在摄取、储存和代谢方面的极化，包括在多发性硬化症 (MS)、镰状细胞病和肿瘤等情况下。
