Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Workers' Stadium South Road, Chaoyang Distinct, Beijing, 100020, China.
Department of Pharmacy, Peking University Third Hospital, No. 49 Huayuan North Road, Haidian District, Beijing, China.
BMC Psychiatry. 2024 Jul 25;24(1):534. doi: 10.1186/s12888-024-05967-x.
Older major depressive disorder (MDD) patients have more complex clinical symptoms and higher abnormal lipid metabolism (ALM) rates. This study aimed to compare clinical differences between those with and without ALM in a sample of older first-episode drug naïve (FEDN) patients.
We recruited 266 older MDD patients. Socio-demographic variables, clinical data, and lipid parameters were obtained. The Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), and the positive subscale of the Positive and Negative Syndrome Scale (PANSS-P) were conducted to evaluate patients' depression, anxiety and psychotic symptoms, respectively.
In this study, we found that the prevalence of comorbid ALM was 86.1% in older MDD patients. Compared with the non-abnormal lipid metabolism (NALM) group, the ALM group had a higher duration of illness, higher clinical global impression of severity scale (CGI-S) and HAMD scores, higher thyroid stimulating hormone (TSH) and glucose levels. Logistic regression analysis indicated that duration of illness (OR = 1.11, P = 0.023, 95%CI = 1.015-1.216) and CGI-S score (OR = 2.28, P = 0.014, 95%CI = 1.18-4.39) were associated with ALM in older MDD patients.
The importance of regular lipid assessment in older MDD patients needs to be taken into account.
老年首发未用药抑郁障碍（FEDN）患者的临床症状更为复杂，血脂代谢异常（ALM）的发生率更高。本研究旨在比较初诊未用药的老年首发抑郁障碍患者中伴发和不伴发 ALM 患者的临床差异。
我们招募了 266 例老年抑郁障碍患者，记录患者的人口统计学变量、临床资料和血脂参数。采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）和阳性与阴性症状量表（PANSS）的阳性症状分量表评估患者的抑郁、焦虑和精神病性症状。
本研究中，老年抑郁障碍患者伴发 ALM 的比例为 86.1%。与非异常脂质代谢（NALM）组相比，ALM 组的病程较长，临床总体印象严重程度量表（CGI-S）和 HAMD 评分较高，促甲状腺激素（TSH）和血糖水平较高。Logistic 回归分析表明，病程（OR=1.11，P=0.023，95%CI=1.015-1.216）和 CGI-S 评分（OR=2.28，P=0.014，95%CI=1.18-4.39）与老年抑郁障碍患者的 ALM 有关。
需要重视老年抑郁障碍患者定期进行血脂评估。
