Zhao Danyang, Han Xiaoli, Mu Qingshuang, Wu Yan, Shan Ligang, Su Lidong, Wang Wenyan, Wang Pengxiang, Kang Yimin, Wang Fan
Medical Neurobiology Lab, Inner Mongolia Medical University, Huhhot, 010110, China.
Clinical Nutrition Department, Friendship hospital of Urumqi in Xinjiang, Urumqi, 830049, China.
Nutr Metab (Lond). 2024 Jul 25;21(1):52. doi: 10.1186/s12986-024-00828-6.
Apoprotein A-I (ApoA-I) and Apoprotein B (ApoB) have emerged as novel cardiovascular risk biomarkers influenced by feeding behavior. Hypothalamic appetite peptides regulate feeding behavior and impact lipoprotein levels, which effects vary in different weight states. This study explores the intricate relationship between body mass index (BMI), hypothalamic appetite peptides, and apolipoproteins with emphasis on the moderating role of body weight in the association between neuropeptide Y (NPY), ghrelin, orexin A (OXA), oxytocin in cerebrospinal fluid (CSF) and peripheral ApoA-I and ApoB.
In this cross-sectional study, we included participants with a mean age of 31.77 ± 10.25 years, categorized into a normal weight (NW) (n = 73) and an overweight/obese (OW/OB) (n = 117) group based on BMI. NPY, ghrelin, OXA, and oxytocin levels in CSF were measured.
In the NW group, peripheral ApoA-I levels were higher, while ApoB levels were lower than in the OW/OB group (all p < 0.05). CSF NPY exhibited a positive correlation with peripheral ApoA-I in the NW group (r = 0.39, p = 0.001). Notably, participants with higher CSF NPY levels had higher peripheral ApoA-I levels in the NW group and lower peripheral ApoA-I levels in the OW/OB group, showing the significant moderating effect of BMI on this association (R = 0.144, β=-0.54, p < 0.001). The correlation between ghrelin, OXA and oxytocin in CSF and peripheral ApoB in both groups exhibited opposing trends (Ghrelin: r = -0.03 and r = 0.04; OXA: r = 0.23 and r=-0.01; Oxytocin: r=-0.09 and r = 0.04).
This study provides hitherto undocumented evidence that BMI moderates the relationship between CSF NPY and peripheral ApoA-I levels. It also reveals the protective role of NPY in the NW population, contrasting with its risk factor role in the OW/OB population, which was associated with the at-risk for cardiovascular disease.
载脂蛋白A-I（ApoA-I）和载脂蛋白B（ApoB）已成为受进食行为影响的新型心血管风险生物标志物。下丘脑食欲肽调节进食行为并影响脂蛋白水平，其作用在不同体重状态下有所不同。本研究探讨体重指数（BMI）、下丘脑食欲肽和载脂蛋白之间的复杂关系，重点关注体重在脑脊液（CSF）中神经肽Y（NPY）、胃饥饿素、食欲素A（OXA）、催产素与外周血ApoA-I和ApoB之间关联中的调节作用。
在这项横断面研究中，我们纳入了平均年龄为31.77±10.25岁的参与者，根据BMI分为正常体重（NW）组（n = 73）和超重/肥胖（OW/OB）组（n = 117）。测量了CSF中NPY、胃饥饿素、OXA和催产素的水平。
在NW组中，外周血ApoA-I水平较高，而ApoB水平低于OW/OB组（所有p < 0.05）。在NW组中，CSF NPY与外周血ApoA-I呈正相关（r = 0.39，p = 0.001）。值得注意的是，CSF NPY水平较高的参与者在NW组中外周血ApoA-I水平较高，而在OW/OB组中外周血ApoA-I水平较低，表明BMI对这种关联具有显著的调节作用（R = 0.144，β = -0.54，p < 0.001）。两组中CSF中的胃饥饿素、OXA和催产素与外周血ApoB之间的相关性呈现相反趋势（胃饥饿素：r = -0.03和r = 0.04；OXA：r = 0.23和r = -0.01；催产素：r = -0.09和r = 0.04）。
本研究提供了迄今未记录的证据，即BMI调节CSF NPY与外周血ApoA-I水平之间的关系。它还揭示了NPY在NW人群中的保护作用，与其在OW/OB人群中的危险因素作用形成对比，后者与心血管疾病风险相关。
