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基于乙醇胺的质子表面活性剂离子液体对乙酰氨基酚在多个温度下溶解度的影响：测量与热力学关联

Effect of protic surfactant ionic liquids based on ethanolamines on solubility of acetaminophen at several temperatures: measurement and thermodynamic correlation.

作者信息

Gondoghdi Parisa Akbarzadeh, Shekaari Hemayat, Mokhtarpour Masumeh, Sardroud Mirhesam Miraghazadeh, Afkari Ramin, Khorsandi Mohammad

机构信息

Department of Physical Chemistry, University of Tabriz, Tabriz, Iran.

Research Center for Bioscience and Biotechnology, University of Tabriz, Tabriz, Iran.

出版信息

BMC Chem. 2024 Jul 25;18(1):136. doi: 10.1186/s13065-024-01243-x.

DOI:10.1186/s13065-024-01243-x
PMID:39054553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11270923/
Abstract

Absolute qualifications with the application of protic ionic liquids (PILs) and a recognition of the numerous thermophysical features of these materials are required in various processes. Due to the wonderful applications of these compounds and their high potential in the chemical and pharmaceutical industries, there is a particular eagerness to utilize these PILs in drug solubility and delivery area. The aim of this investigation was to explore the solubility of the acetaminophen (ACP) in three PILs base on ethanolamine laurate [(2-hydroxyethylammonium laurate [MEA]La), (bis(2-hydroxyethyl)ammonium laurate [DEA]La), and ( tris(2-hydroxyethyl)ammonium laurate [TEA]La)]. The shake flask method has been employed in this study, and the conditions were set at T = (298.15-313.15) K and atmospheric pressure. Moreover, the experimental solubility data was correlated using a variety of empirical and thermodynamic models, encompassing e-NRTL and Wilson activity coefficient models and the empirical models such as Van't Hoff-Jouyban-Acree and Modified Apelblat-Jouyban-Acree. Their performance for the system containing [MEA]La follow the trend for activity coefficient models and empirical respectively: the Wilson > e-NRTL and Modified Apelblat-Jouyban-Acree > Van't Hoff-Jouyban-Acree. On the other hand, [DEA]La and [TEA]La PILs followed slightly different trend for activity coefficient models and empirical respectively: the Wilson > e-NRTL and Van't Hoff-uyban-Acree > Modified Apelblat-Jouyban-Acree. The Van't Hoff and Gibbs equations were used to determine the thermodynamic properties of dissolution in the studied systems.

摘要

在各种过程中，质子离子液体（PILs）的应用以及对这些材料众多热物理特性的认识都需要有绝对的条件。由于这些化合物的出色应用及其在化学和制药行业的巨大潜力，人们特别渴望在药物溶解度和递送领域使用这些质子离子液体。本研究的目的是探索对乙酰氨基酚（ACP）在三种基于月桂酸乙醇胺的质子离子液体（[2-羟乙基铵月桂酸盐[MEA]La、双(2-羟乙基)铵月桂酸盐[DEA]La和三(2-羟乙基)铵月桂酸盐[TEA]La）中的溶解度。本研究采用了摇瓶法，条件设定为T =（298.15 - 313.15）K和大气压。此外，实验溶解度数据使用了多种经验和热力学模型进行关联，包括e-NRTL和Wilson活度系数模型以及诸如Van't Hoff-Jouyban-Acree和修正的Apelblat-Jouyban-Acree等经验模型。它们对含有[MEA]La的体系的性能分别遵循活度系数模型和经验模型的趋势：Wilson＞e-NRTL，修正的Apelblat-Jouyban-Acree＞Van't Hoff-Jouyban-Acree。另一方面，[DEA]La和[TEA]La质子离子液体在活度系数模型和经验模型方面分别遵循略有不同的趋势：Wilson＞e-NRTL，Van't Hoff-Jouyban-Acree＞修正的Apelblat-Jouyban-Acree。使用Van't Hoff和Gibbs方程来确定所研究体系中溶解的热力学性质。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a91/11270923/9b89ee7c017b/13065_2024_1243_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a91/11270923/3e7dfe1370bb/13065_2024_1243_Fig6_HTML.jpg
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