Wang Huizhe, Liu Huijia, Li Wenqing, Li Shuai, Zhang Jiaqi, Zang Jingzhe, Liu Li, Wang Peng
Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University Nanjing 210009 China
Chem Sci. 2024 Jun 24;15(29):11347-11357. doi: 10.1039/d4sc03020f. eCollection 2024 Jul 24.
Rational design of small organic molecule-based NIR-II photosensitizers (PSs) with high singlet oxygen quantum yield in aqueous solution for deep tissue imaging and cancer therapy still presents challenges. Herein, we devised a general synthesis strategy to obtain six NIR-II region PSs with tunable aggregation states by adjusting the steric effect, and all PSs possess longer NIR absorption/emission wavelengths with tails extending beyond 1200 nm. Notably, ATX-6 possessed a singlet oxygen quantum yield of 38.2% and exhibited concentration-dependent J-aggregation properties upon self-assembly in an aqueous solution. What's more, supramolecular engineering with DSPE-PEG further enhanced its degree of J-aggregation, which was attributed to the dimer-excited reduction of the energy levels of the single-linear/triple-linear states and the facilitation of intersystem crossover processes. In addition, ATX-6 NPs showed superior photodynamic therapy effects and great potential in high-contrast bioimaging of the NIR-II region. These results provide valuable insights for achieving the diagnostic and therapeutic integration of tumors.
合理设计基于小分子有机化合物的近红外二区（NIR-II）光敏剂（PSs），使其在水溶液中具有高单线态氧量子产率，用于深部组织成像和癌症治疗，仍然面临挑战。在此，我们设计了一种通用合成策略，通过调节空间效应获得六种具有可调聚集态的NIR-II区域PSs，所有PSs都具有更长的近红外吸收/发射波长，其尾部延伸超过1200 nm。值得注意的是，ATX-6的单线态氧量子产率为38.2%，在水溶液中自组装时表现出浓度依赖性J-聚集特性。此外，用DSPE-PEG进行超分子工程进一步增强了其J-聚集程度，这归因于单线态/三线态能级的二聚体激发还原以及对系间窜越过程的促进。此外，ATX-6纳米颗粒显示出优异的光动力治疗效果，在NIR-II区域的高对比度生物成像中具有巨大潜力。这些结果为实现肿瘤的诊断和治疗一体化提供了有价值的见解。
