Jiangxi Key Laboratory of Nanobiomaterials, School of Materials Science and Engineering, East China Jiaotong University, Nanchang, 330013, China.
Strait Laboratory of Flexible Electronics (SLoFE), Strait Institute of Flexible Electronics (SIFE, Future Technologies), Fujian Normal University, Fuzhou, Fujian, 350117, China.
Adv Mater. 2024 Jan;36(1):e2304848. doi: 10.1002/adma.202304848. Epub 2023 Nov 7.
Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for in vivo deep-tissue bioimaging and high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters and show unique superiority in tumor detection, vessel mapping, surgical navigation, and phototheranostics due to their bathochromic-shifted optical bands in the required slip-stacked arrangement aggregation state. However, despite the preliminary progress of NIR-II J-aggregates and theoretical study of structure-property relationships, further paradigms of NIR-II J-aggregates remain scarce due to the lack of study on aggregated fluorophores with slip-stacked fashion. In this effort, how to utilize the specific molecular structure to form slip-stacked packing motifs with J-type aggregated exciton coupling is emphatically elucidated. First, several molecular regulating strategies to achieve NIR-II J-aggregates containing intermolecular interactions and external conditions are positively summarized and deeply analyzed. Then, the recent reports on J-aggregates for NIR-II bioimaging and theranostics are systematically summarized to provide a clear reference and direction for promoting the development of NIR-II organic fluorophores. Eventually, the prospective efforts on ameliorating and promoting NIR-II J-aggregates to further clinical practices are outlined.
在近红外二区（NIR-II，1000-1700nm）窗口中发射的分子荧光团具有很强的光学采集能力和高量子产率，在体内深层组织生物成像和高分辨率生物传感方面具有巨大的潜力。最近，J-聚集体被用于设计长波长 NIR-II 发射器，由于其在所需的滑移堆积排列聚集态下的红移光学带，在肿瘤检测、血管成像、手术导航和光热治疗方面表现出独特的优势。然而，尽管 NIR-II J-聚集体取得了初步进展，并对结构-性能关系进行了理论研究，但由于缺乏对具有滑移堆积方式的聚集荧光团的研究，进一步的 NIR-II J-聚集体范例仍然很少。在这项工作中，强调并深入阐明了如何利用特定的分子结构来形成具有 J 型聚集激子耦合的滑移堆积堆积模式。首先，积极总结和深入分析了几种实现含有分子间相互作用和外部条件的 NIR-II J-聚集体的分子调节策略。然后，系统总结了用于 NIR-II 生物成像和治疗的 J-聚集体的最新报告，为促进 NIR-II 有机荧光团的发展提供了清晰的参考和方向。最终，概述了改善和促进 NIR-II J-聚集体以进一步临床应用的预期努力。
