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用于选择性递送mRNA疫苗以引发增强免疫反应的树突状细胞靶向自组装聚合物纳米颗粒的合成。

Synthesis of a dendritic cell-targeted self-assembled polymeric nanoparticle for selective delivery of mRNA vaccines to elicit enhanced immune responses.

作者信息

Fan Chen-Yo, Wang Szu-Wen, Chung Cinya, Chen Jia-Yan, Chang Chia-Yen, Chen Yu-Chen, Hsu Tsui-Ling, Cheng Ting-Jen R, Wong Chi-Huey

机构信息

Genomics Research Center, Academia Sinica Taipei 115 Taiwan.

Department of Chemistry, The Scripps Research Institute La Jolla California 92037 USA

出版信息

Chem Sci. 2024 Jun 25;15(29):11626-11632. doi: 10.1039/d3sc06575h. eCollection 2024 Jul 24.

DOI:10.1039/d3sc06575h
PMID:39055027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11268467/
Abstract

Recent development of SARS-CoV-2 spike mRNA vaccines to control the pandemic is a breakthrough in the field of vaccine development. mRNA vaccines are generally formulated with lipid nanoparticles (LNPs) which are composed of several lipids with specific ratios; however, they generally lack selective delivery. To develop a selective delivery method for mRNA vaccine formulation, we reported here the synthesis of polymeric nanoparticles (PNPs) composed of a guanidine copolymer containing zwitterionic groups and a dendritic cell (DC)-targeted aryl-trimannoside ligand for encapsulation and selective delivery of an mRNA to dendritic cells. A DC-targeted SARS-CoV-2 spike mRNA-PNP vaccine was shown to elicit a stronger protective immune response in mice compared to the traditional mRNA-LNP vaccine and those without the selective delivery design. It is anticipated that this technology is generally applicable to other mRNA vaccines for DC-targeted delivery with enhanced immune response.

摘要

新型冠状病毒刺突mRNA疫苗用于控制疫情的最新进展是疫苗研发领域的一项突破。mRNA疫苗通常与脂质纳米颗粒（LNP）一起配制，脂质纳米颗粒由几种特定比例的脂质组成；然而，它们通常缺乏选择性递送。为了开发一种用于mRNA疫苗制剂的选择性递送方法，我们在此报告了由含两性离子基团的胍共聚物和树突状细胞（DC）靶向芳基三甘露糖苷配体组成的聚合物纳米颗粒（PNP）的合成，用于将mRNA封装并选择性递送至树突状细胞。与传统的mRNA-LNP疫苗和没有选择性递送设计的疫苗相比，一种DC靶向的新型冠状病毒刺突mRNA-PNP疫苗在小鼠中显示出更强的保护性免疫反应。预计该技术通常适用于其他用于DC靶向递送并增强免疫反应的mRNA疫苗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/1d5755661f5d/d3sc06575h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/74fc6d796858/d3sc06575h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/f3328fb7020f/d3sc06575h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/e8f751962aa6/d3sc06575h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/89ad127e70fa/d3sc06575h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/1d5755661f5d/d3sc06575h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/74fc6d796858/d3sc06575h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/f3328fb7020f/d3sc06575h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/e8f751962aa6/d3sc06575h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/89ad127e70fa/d3sc06575h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a15/11268467/1d5755661f5d/d3sc06575h-f5.jpg

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本文引用的文献

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