Kurien Biji T, Fesmire James, Nath Swapan K, Scofield R Hal
Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Department of Veterans Affairs Medical Center, Oklahoma City, OK, United States.
Front Lupus. 2023;1. doi: 10.3389/flupu.2023.1197309. Epub 2023 Sep 26.
Premature atherosclerosis is associated with systemic lupus erythematosus (SLE). We have previously shown an association of anti-Ro60/La/Ro52 with antioxidized low-density lipoprotein (LDL) in SLE. Here, we hypothesized that carotid intima-media thickening (CIMT) would be associated with antioxidized LDL (anti-oxLDL)/antilipoprotein lipase (ALPL) in a specific SLE autoantibody subset (anti-Ro60 positive, anti-RNP positive, anti-SmRNP positive, or extractable nuclear antigen antibody negative).
We carried out a case-control study (one time-point testing) of CIMT, ALPL, anti-oxLDL, anti-low density lipoprotein (ALDL), and anti-LDL in 114 SLE patients and 117 age/sex-matched controls. The levels of total cholesterol, LDL, high-density lipoprotein (HDL), triglycerides, and HDL-Trig were also measured. A student's -test was used for statistical analysis.
Interestingly, the level of CIMT was highest in the SLE subset with anti-Ro60 (23/114). CIMT and anti-oxLDL were statistically significantly elevated in the anti-Ro60 SLE subset (1.3 ± 1.66, < 0.01; 0.26 ± 0.16, < 0.002, respectively) compared with controls (0.54 ± 1.26; 0.165 ± 0.13, respectively), but not anti-LPL/anti-LDL. CIMT was significantly elevated (0.9 ± 1.71; < 0.05) in the SLE subset without antiextractable nuclear antigen (ENA) (63/114) compared with controls. The other antibodies in this subset were not statistically different from other SLE subsets or controls. Only antioxLDL was significantly elevated (0.29 ± 0.27; < 0.005) in the SLE subset with anti-RNP (14/114) compared with controls, while none were elevated in the anti-SmRNP subset (6/114). We did not find any significant differences in lipids between the various SLE subsets.
CIMT segregates in anti-Ro and ENA negative groups either with or without anti-oxLDL. It will be clinically important if cardiovascular events are augmented in the SLE anti-Ro subset having elevated antioxidized LDL antibodies.
动脉粥样硬化过早发生与系统性红斑狼疮（SLE）相关。我们之前已表明SLE患者中抗Ro60/La/Ro52与氧化型低密度脂蛋白（LDL）有关联。在此，我们假设在特定的SLE自身抗体亚组（抗Ro60阳性、抗RNP阳性、抗SmRNP阳性或可提取核抗原抗体阴性）中，颈动脉内膜中层增厚（CIMT）会与氧化型LDL（抗oxLDL）/抗脂蛋白脂肪酶（ALPL）相关。
我们对114例SLE患者和117例年龄/性别匹配的对照者进行了CIMT、ALPL、抗oxLDL、抗低密度脂蛋白（ALDL）和抗LDL的病例对照研究（单点检测）。还测量了总胆固醇、LDL、高密度脂蛋白（HDL）、甘油三酯和HDL - 甘油三酯的水平。采用学生t检验进行统计分析。
有趣的是，在抗Ro60的SLE亚组（23/114）中CIMT水平最高。与对照组（分别为0.54±1.26；0.165±0.13）相比，抗Ro60的SLE亚组中CIMT和抗oxLDL在统计学上显著升高（分别为1.3±1.66，P<0.01；0.26±0.16，P<0.002），但抗LPL/抗LDL无此现象。与对照组相比，无抗可提取核抗原（ENA）的SLE亚组（63/114）中CIMT显著升高（0.9±1.71；P<0.05）。该亚组中的其他抗体与其他SLE亚组或对照组相比无统计学差异。与对照组相比，抗RNP的SLE亚组（14/114）中仅抗oxLDL显著升高（0.29±0.27；P<0.005），而抗SmRNP亚组（6/114）中均无升高。我们未发现各SLE亚组之间血脂有任何显著差异。
无论有无抗oxLDL，CIMT在抗Ro和ENA阴性组中存在差异。如果在具有升高的氧化型LDL抗体的SLE抗Ro亚组中心血管事件增加，将具有临床重要性。
