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通过补充烟酰胺腺嘌呤二核苷酸（NAD）恢复能量代谢可预防酒精性肝损伤并促进肝脏再生。

Restoring energy metabolism by NAD supplement prevents alcohol-induced liver injury and boosts liver regeneration.

作者信息

Liu Yao, Cheng Cheng, Gao Han, Zhu Xue-Jin, He Xian, Zhou Ming-Xi, Gao Yuan, Lu Ya-Wen, Song Xin-Hua, Xiao Xiao-He, Wang Jia-Bo, Xu Chun-Jun, Ma Zhi-Tao

机构信息

School of Traditional Chinese Medicine Capital Medical University Beijing China.

Department of Infectious Disease, Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing China.

出版信息

Food Sci Nutr. 2024 Apr 22;12(7):5100-5110. doi: 10.1002/fsn3.4159. eCollection 2024 Jul.

DOI:10.1002/fsn3.4159
PMID:39055233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11266918/
Abstract

Our previous clinical metabolomics study illustrated that energy metabolism disorder is an underlying pathogenesis mechanism for the development of alcoholic liver disease (ALD). Supplementation of nicotinamide (NAM), the precursor of nicotinamide adenine dinucleotide (NAD), may restore the energy metabolism homeostasis of ALD and thus serves as potential therapeutics to treat ALD. In this bedside-to-bench study, the protective effect of NAM against ALD was investigated by using the NIAAA mice model (chronic-plus-binge ethanol), and the liver regeneration boosting capability of NAM was evaluated by the partial hepatectomy mice model. Our results showed that NAM supplements not only protected the liver from alcohol-induced injury and improved alcohol-induced mitochondrial structure and function change, but also boosted liver regeneration in postpartial hepatectomy mice by increasing liver NAD content. These findings suggested that NAM, a water-soluble form of vitamin B3, can promote liver regeneration and improves liver function by alleviating alcohol-induced energy metabolism disorder.

摘要

我们之前的临床代谢组学研究表明，能量代谢紊乱是酒精性肝病（ALD）发生发展的潜在发病机制。补充烟酰胺（NAM），即烟酰胺腺嘌呤二核苷酸（NAD）的前体，可能恢复ALD的能量代谢稳态，从而成为治疗ALD的潜在疗法。在这项从床边到实验室的研究中，我们使用NIAAA小鼠模型（慢性加暴饮乙醇）研究了NAM对ALD的保护作用，并通过部分肝切除小鼠模型评估了NAM促进肝脏再生的能力。我们的结果表明，补充NAM不仅能保护肝脏免受酒精诱导的损伤，改善酒精诱导的线粒体结构和功能变化，还能通过增加肝脏NAD含量促进部分肝切除术后小鼠的肝脏再生。这些发现表明，作为维生素B3的水溶性形式，NAM可以通过减轻酒精诱导的能量代谢紊乱来促进肝脏再生并改善肝功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/1a5a623256ab/FSN3-12-5100-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/e792a7bc2297/FSN3-12-5100-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/53e6b7a386bb/FSN3-12-5100-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/354666f5d8cf/FSN3-12-5100-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/0f95177abf5a/FSN3-12-5100-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/dea8adcacfa6/FSN3-12-5100-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/1a5a623256ab/FSN3-12-5100-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/e792a7bc2297/FSN3-12-5100-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/53e6b7a386bb/FSN3-12-5100-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/354666f5d8cf/FSN3-12-5100-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/0f95177abf5a/FSN3-12-5100-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/dea8adcacfa6/FSN3-12-5100-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b721/11266918/1a5a623256ab/FSN3-12-5100-g005.jpg

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Front Med (Lausanne). 2022 Jun 13;9:815467. doi: 10.3389/fmed.2022.815467. eCollection 2022.
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Diagnosis and Treatment of Alcohol-Associated Liver Disease: A Review.酒精相关性肝病的诊断与治疗：综述
JAMA. 2021 Jul 13;326(2):165-176. doi: 10.1001/jama.2021.7683.
3
Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol-Associated Liver Cirrhosis.
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Hepatol Commun. 2021 Mar 8;5(6):961-975. doi: 10.1002/hep4.1699. eCollection 2021 Jun.
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EMBO Mol Med. 2021 Jul 7;13(7):e13943. doi: 10.15252/emmm.202113943. Epub 2021 May 27.
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Redox Biol. 2021 Jul;43:101988. doi: 10.1016/j.redox.2021.101988. Epub 2021 Apr 24.
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