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丙戊酸盐治疗后意外发生白内障:一例报告

Unexpected Cataract Formation Following Valproate Treatment: A Case Report.

作者信息

Sinha Nayan, Patil Pradeep S, Ananta Aditi, Suresh Sneha B, Unni Navaneetha

机构信息

Psychiatry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Wardha, IND.

Ophthalmology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Nagpur, IND.

出版信息

Cureus. 2024 Jun 25;16(6):e63093. doi: 10.7759/cureus.63093. eCollection 2024 Jun.

DOI:10.7759/cureus.63093
PMID:39055475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11272151/
Abstract

Valproic acid (VPA), or sodium valproate, is a frequently prescribed medication for many psychiatric conditions, notably for the management of bipolar affective disorder. While its common side effects are well known and thoroughly documented in medical literature, the occurrence of cataracts as a side effect is exceedingly rare. There is evidence of cataract formation with long-term use of VPA in a few studies. Recognizing this potential adverse effect is crucial. It is important to recommend that patients undergo regular eye examinations if they experience any visual disturbances or as a preventative measure to ensure effective management. This case report examines the unusual occurrence of cataract development associated with valproate use.

摘要

丙戊酸(VPA)或丙戊酸钠是常用于治疗多种精神疾病的药物,尤其用于治疗双相情感障碍。虽然其常见副作用在医学文献中广为人知且有详尽记录,但白内障作为一种副作用的发生极为罕见。一些研究中有证据表明长期使用VPA会形成白内障。认识到这种潜在的不良反应至关重要。如果患者出现任何视觉障碍,建议其定期进行眼部检查,或者作为一种预防措施以确保有效管理,这一点很重要。本病例报告探讨了与丙戊酸盐使用相关的白内障发展这一不寻常情况。

相似文献

1
Unexpected Cataract Formation Following Valproate Treatment: A Case Report.丙戊酸盐治疗后意外发生白内障:一例报告
Cureus. 2024 Jun 25;16(6):e63093. doi: 10.7759/cureus.63093. eCollection 2024 Jun.
2
Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder.丙戊酸、丙戊酸盐及丙戊酸镁用于双相情感障碍的维持治疗
Cochrane Database Syst Rev. 2013 Oct 17;2013(10):CD003196. doi: 10.1002/14651858.CD003196.pub2.
3
[Antipsychotics in bipolar disorders].[双相情感障碍中的抗精神病药物]
Encephale. 2004 Sep-Oct;30(5):417-24. doi: 10.1016/s0013-7006(04)95456-5.
4
Does valproic acid warrant therapeutic drug monitoring in bipolar affective disorder?丙戊酸在双相情感障碍中是否需要治疗药物监测?
Ther Drug Monit. 2010 Feb;32(1):19-29. doi: 10.1097/FTD.0b013e3181c13a30.
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Is intravenous valproate more efficacious than oral valproate for inpatients with bipolar I disorder with a manic or depressive episode and concomitant symptoms of opposite polarity?静脉用丙戊酸钠对于伴有相反极性伴随症状的双相 I 障碍住院患者的躁狂或抑郁发作是否比口服丙戊酸钠更有效?
Bipolar Disord. 2024 May;26(3):277-283. doi: 10.1111/bdi.13388. Epub 2023 Nov 13.
6
Sodium valproate induced acute pancreatitis in a bipolar disorder patient: a case report.丙戊酸钠致双相障碍患者急性胰腺炎 1 例报告
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Valproate for acute mood episodes in bipolar disorder.丙戊酸盐用于双相情感障碍的急性情绪发作
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Clinical and pathophysiological characteristics of valproate-induced pleural effusion.丙戊酸盐相关性胸腔积液的临床及病理生理学特征。
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Rapid reversal of corticosteroid-induced mania with sodium valproate: a case series of 20 patients.丙戊酸钠快速逆转皮质类固醇诱导的躁狂症:20 例病例系列。
Psychosomatics. 2012 Nov-Dec;53(6):575-81. doi: 10.1016/j.psym.2012.06.006.
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Valproate-Induced Hyperammonemic Encephalopathy Causing New-Onset Seizures.丙戊酸盐诱导的高氨血症性脑病引发新发癫痫
Cureus. 2023 Oct 18;15(10):e47288. doi: 10.7759/cureus.47288. eCollection 2023 Oct.

本文引用的文献

1
Rapidly Developing Cataract in Young Adult Patients: Always a Matter for Further Evaluation.年轻成年患者中的快速进展性白内障:始终需要进一步评估。
Cureus. 2021 Aug 19;13(8):e17312. doi: 10.7759/cureus.17312. eCollection 2021 Aug.
2
Sodium valproate-induced cataract.丙戊酸钠所致白内障。
BMJ Case Rep. 2021 Jan 27;14(1):e240997. doi: 10.1136/bcr-2020-240997.
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Presenile cataract and its risk factors: A case control study.早老性白内障及其危险因素:一项病例对照研究。
J Family Med Prim Care. 2019 Jun;8(6):2120-2123. doi: 10.4103/jfmpc.jfmpc_267_19.
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Associations between use of mood stabilizers and risk of cataract: A population-based nested case-control study.心境稳定剂的使用与白内障风险之间的关联:基于人群的巢式病例对照研究。
J Affect Disord. 2018 Feb;227:79-81. doi: 10.1016/j.jad.2017.10.017. Epub 2017 Oct 5.
5
Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells.丙戊酸通过诱导人晶状体上皮细胞内质网应激和 Keap1 启动子 DNA 去甲基化来抑制 Nrf2/Keap1 依赖性抗氧化保护。
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Fatal acute pancreatitis caused by valproic acid.丙戊酸导致的致命性急性胰腺炎。
Am J Forensic Med Pathol. 1995 Mar;16(1):62-5. doi: 10.1097/00000433-199503000-00014.
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