Nazeri Astaneh Ali, Jafari Neda, Sadighi Gita
Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Iran J Psychiatry. 2024 Jul;19(3):265-273. doi: 10.18502/ijps.v19i3.15803.
Manic and mixed episodes of bipolar disorder are important episodes of this disorder. The aim of the current study was to assess serum vitamin D (SVD) levels in patients with mania and mixed bipolar disorder, compared to healthy subjects. The current cross-sectional study was conducted on 75 subjects, including healthy subjects (n = 25), patients with acute-phase mania (n = 25), and patients with mixed bipolar disorder (n = 25). The SVD levels were measured in all of the enrolled subjects. The Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), and Clinical Global Impression- Severity (CGI-S) were used to assess disease activity in patient groups. Data analysis was performed using SPSS version 18. For statistical analysis, analysis of variance (ANOVA), independent-sample t test, Pearson correlation, and Chi-square tests were utilized. P-values < 0.05 were considered statistically significant. The results showed that the mean of SVD was significantly lower in mania and mixed bipolar patients compared to healthy subjects (P < 0.05). In addition, the number of subjects with SVD ≥ 20 ng/ml was higher in the healthy group compared to the patient groups (P < 0.05). Also, SVD was negatively correlated with the CGI-S (r = -0.311; P = 0.028), YMRS (r = -0.464; P = 0.001), and HDRS (r = -0.393; P = 0.005) in the total patient subjects. Prevalence of low SVD was considerably high in mania and mixed bipolar patients compared to healthy subjects. Additionally, meaningful negative correlations were found between SVD and disease activity-related variables including the HDRS, YMRS, and CGI-S.
双相情感障碍的躁狂发作和混合发作是该疾病的重要发作类型。本研究的目的是评估躁狂发作和双相混合性障碍患者的血清维生素D（SVD）水平，并与健康受试者进行比较。 本横断面研究共纳入75名受试者，包括健康受试者（n = 25）、急性期躁狂患者（n = 25）和双相混合性障碍患者（n = 25）。对所有纳入的受试者测量SVD水平。使用汉密尔顿抑郁评定量表（HDRS）、杨氏躁狂评定量表（YMRS）和临床总体印象-严重程度（CGI-S）来评估患者组的疾病活动度。使用SPSS 18版进行数据分析。对于统计分析，采用方差分析（ANOVA）、独立样本t检验、Pearson相关性分析和卡方检验。P值<0.05被认为具有统计学意义。 结果显示，与健康受试者相比，躁狂发作和双相混合性障碍患者的SVD均值显著降低（P < 0.05）。此外，SVD≥20 ng/ml的受试者数量在健康组中高于患者组（P < 0.05）。而且，在所有患者受试者中，SVD与CGI-S（r = -0.311；P = 0.028）、YMRS（r = -0.464；P = 0.001）和HDRS（r = -0.393；P = 0.005）呈负相关。与健康受试者相比，躁狂发作和双相混合性障碍患者中低SVD的患病率相当高。此外，还发现SVD与包括HDRS、YMRS和CGI-S在内的疾病活动相关变量之间存在有意义的负相关。
