Domański Igor, Kozieł Aleksandra, Kuderska Natalia, Wójcik Paulina, Dudzik Łucja, Dudzik Tomasz
Lower Silesian Oncology, Pulmonology and Hematology Center, Wroclaw, Poland.
Family Medicine Practice, Wroclaw, Poland.
Reumatologia. 2024;62(3):207-213. doi: 10.5114/reum/189998. Epub 2024 Jul 1.
Hyperuricemia, characterized by elevated levels of uric acid in the body, is associated with several health risks, including gout, urolithiasis and cardiovascular disease. Although treatment options are available, they can lead to hypersensitivity reactions, particularly with allopurinol therapy. This paper provides a comprehensive review of the consequences of hyperuricemia, the need for treatment and the potential adverse effects of allopurinol, illustrated by a case study. The study highlights the importance of careful consideration before initiating therapy, particularly in patients with comorbidities and concomitant medication. It emphasizes the need for vigilant monitoring and individualized treatment approaches to reduce adverse effects. In addition, genetic factors, particularly HLA-B*5801, play an important role in determining susceptibility to allopurinol hypersensitivity reactions. This paper highlights the importance of informed decision making in the management of hyperuricemia to optimize patient outcomes while minimizing the risks associated with treatment.
高尿酸血症的特征是体内尿酸水平升高，与多种健康风险相关，包括痛风、尿路结石和心血管疾病。尽管有治疗方案可供选择，但它们可能会导致过敏反应，尤其是在使用别嘌醇治疗时。本文通过一个案例研究，全面回顾了高尿酸血症的后果、治疗需求以及别嘌醇的潜在不良反应。该研究强调了在开始治疗前仔细考虑的重要性，特别是对于患有合并症和正在服用其他药物的患者。它强调了进行 vigilant 监测和采用个体化治疗方法以减少不良反应的必要性。此外，遗传因素，特别是 HLA - B*5801，在确定对别嘌醇过敏反应的易感性方面起着重要作用。本文强调了在高尿酸血症管理中做出明智决策的重要性，以优化患者预后，同时将与治疗相关的风险降至最低。
“vigilant”未找到合适中文对应词，暂保留英文。
