Wang Fang, Zheng XuDong, Ni Xiang, Li Ying
Department of The Health Management Center, The First Affiliated Hospital of USTC: Anhui Provincial Hospital (South District), Hefei, 230001, Anhui, China.
Department of Endocrinology, The First People's Hospital of Hefei, No. 3200, Changsha Road, Binhu new district, An hui Province, Hefei City, 230001, China.
Sci Rep. 2025 Jul 24;15(1):26941. doi: 10.1038/s41598-025-09073-0.
To investigate the correlation between the serum uric acid to creatinine ratio (SUA/SCr) and the severity of hepatic steatosis in individuals with MASLD. A total of 34,981 individuals were measured the controlled attenuated parameter (CAP) using transient elastography (TE), then we studied the association between SUA/SCr and the severity of hepatic steatosis defined with the value of CAP. A cohort of 2179 individuals without MASLD were followed up to investigate the relationship between SUA/SCr and the incidence of MASLD during the following 33 months. After adjusting for confounding factors, smooth fitting curve and threshold saturation analysis showed that SUA/SCr exhibited a significant positive correlation with CAP (P < 0.0001), with different inflection points in sex, BMI and age subgroups. Logistic regression analysis showed that SUA/SCr demonstrated a certain degree of predictive value for MASLD (P < 0.001). In followed-up population, individuals with higher SUA/SCr exhibited a significantly increased cumulative incidence of MASLD (P = 0.0008). Increased SUA/SCr levels are associated with the severity of hepatic steatosis in MASLD, is an independent risk factor for MASLD. Individuals with elevated levels of SUA/SCr are at a higher risk of developing MASLD. Maybe SUA/SCr could be considered as a useful biomarker for MASLD in clinical work, although the predictive value is limited, and further validation and combined usage with other markers are necessary.
探讨非酒精性脂肪性肝病（MASLD）患者血清尿酸与肌酐比值（SUA/SCr）与肝脂肪变性严重程度之间的相关性。共34981例个体采用瞬时弹性成像（TE）测量受控衰减参数（CAP），然后研究SUA/SCr与以CAP值定义的肝脂肪变性严重程度之间的关联。对2179例无MASLD的个体进行随访，以调查SUA/SCr与接下来33个月内MASLD发病率之间的关系。在调整混杂因素后，平滑拟合曲线和阈值饱和分析显示，SUA/SCr与CAP呈显著正相关（P<0.0001），在性别、BMI和年龄亚组中有不同的拐点。逻辑回归分析显示，SUA/SCr对MASLD具有一定的预测价值（P<0.001）。在随访人群中，SUA/SCr较高的个体MASLD累积发病率显著增加（P=0.0008）。SUA/SCr水平升高与MASLD患者肝脂肪变性严重程度相关，是MASLD的独立危险因素。SUA/SCr水平升高的个体发生MASLD的风险更高。尽管预测价值有限，且需要进一步验证并与其他标志物联合使用，但在临床工作中，SUA/SCr可能可被视为MASLD的有用生物标志物。
