Zhao Wenjian, Zhu Yuezhi, Wong Sok Kuan, Muhammad Norliza, Pang Kok-Lun, Chin Kok-Yong
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000, Cheras, Malaysia.
Department of Pathology, College of Basic Medicine, Xiangnan University, 423000, Chenzhou City, China.
Heliyon. 2024 Jul 4;10(13):e34064. doi: 10.1016/j.heliyon.2024.e34064. eCollection 2024 Jul 15.
Osteoarthritis (OA) is the most common age-related disease of joints with increasing global prevalence. Persistent inflammation within the joint space is speculated to be the cause of OA. Resveratrol is an anti-inflammatory and antioxidant compound which can influence cartilage metabolism through multiple signalling pathways. This systematic review and meta-analysis aimed to summarize the therapeutic effects of resveratrol in animal models of OA.
A comprehensive literature search was performed using PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, China Wanfang and VIP databases in May 2023. Studies on the effects of resveratrol in animal models of OA written in English or Mandarin, published from the inception of databases until the date of the search were considered.
Fifteen eligibility studies were included and analysed. Resveratrol was shown to inhibit the secretion of interleukin-1β, tumour necrosis factor-α, interleukin-6, nitric oxide, and apoptosis of articular chondrocytes. Joint structure as indicated by Mankin scores was restored with resveratrol in animal OA models.
Resveratrol is a potential therapeutic agent for OA based on animal studies. Further evidence from well-planned human studies would be required to validate its clinical efficacies.
骨关节炎（OA）是最常见的与年龄相关的关节疾病，在全球范围内患病率不断上升。关节腔内持续的炎症被推测为OA的病因。白藜芦醇是一种抗炎和抗氧化化合物，可通过多种信号通路影响软骨代谢。本系统评价和荟萃分析旨在总结白藜芦醇在OA动物模型中的治疗效果。
于2023年5月使用PubMed、Embase、Web of Science、Cochrane图书馆、中国知网、中国万方和维普数据库进行了全面的文献检索。纳入从数据库建立至检索日期发表的、用英文或中文撰写的关于白藜芦醇在OA动物模型中作用的研究。
纳入并分析了15项符合条件的研究。结果表明，白藜芦醇可抑制白细胞介素-1β、肿瘤坏死因子-α、白细胞介素-6、一氧化氮的分泌以及关节软骨细胞的凋亡。在动物OA模型中，白藜芦醇可使Mankin评分所显示的关节结构得到恢复。
基于动物研究，白藜芦醇是一种有潜力的OA治疗药物。需要精心设计的人体研究提供进一步证据来验证其临床疗效。
