Behbehani Raed, Ali Abdullah, Alakool Ahmed, Farouk Samar, Alroughani Raed
Al-Bahar Ophthalmology Center, Ibn Sina Hospital, Kuwait.
Neurology Department, Ibn Sina Hospital, Kuwait.
Heliyon. 2024 Jul 2;10(13):e33985. doi: 10.1016/j.heliyon.2024.e33985. eCollection 2024 Jul 15.
Optic neuritis is an inflammatory disorder of the optic nerve and is often the initial manifestation of systemic demyelinating diseases such as multiple sclerosis (MS), neuromyelitis optic spectrum disorder (NMOSD), and myelin-oligodendrocyte glycoprotein (MOG) antibody-mediated disease. There are ethnic variations in the etiology of optic neuritis across the world. While multiple sclerosis is common in the West, NMOSD and MOG are more common causes in Asian patients. There is a paucity of reports on the clinical profile of optic neuritis in the Middle East.
To study the demographic and clinical features of patients with new onset optic neuritis in a main tertiary care center.
A retrospective study of cases with new-onset optic neuritis at a tertiary care center between 2012 and 2022. The clinical and demographic characteristics were obtained from medical records and were summarized using descriptive statistics. Univariate analysis and multivariate analysis to assess the short-term visual outcome.
Seventy-one patients with new-onset optic neuritis (70 unilateral and one bilateral) were included in the study. The mean age was 33.3 years, they were predominantly females (73 %), and most of the cases were MS (53 %) followed by idiopathic optic neuritis (42.3 %). Final visual acuity of at least 20/40 was seen in at least 91.5 %.
While the clinical profile of patients in this study closely resembles the Optic Neuritis Treatment Trial with a high incidence of MS and a good visual outcome in most patients and a good response to intravenous steroids, there is a significant proportion of idiopathic optic neuritis cases that may need to be better characterized with longer follow up and repeated serum biomarker testing.
视神经炎是一种视神经的炎症性疾病，通常是系统性脱髓鞘疾病的初始表现，如多发性硬化症（MS）、视神经脊髓炎谱系障碍（NMOSD）和髓鞘少突胶质细胞糖蛋白（MOG）抗体介导的疾病。世界各地视神经炎的病因存在种族差异。虽然多发性硬化症在西方很常见，但NMOSD和MOG在亚洲患者中是更常见的病因。中东地区关于视神经炎临床特征的报道很少。
研究一家主要三级医疗中心新发视神经炎患者的人口统计学和临床特征。
对2012年至2022年期间一家三级医疗中心新发视神经炎病例进行回顾性研究。从病历中获取临床和人口统计学特征，并使用描述性统计进行总结。采用单因素分析和多因素分析评估短期视力预后。
71例新发视神经炎患者（70例单侧，1例双侧）纳入研究。平均年龄为33.3岁，以女性为主（73%），大多数病例为MS（53%），其次是特发性视神经炎（42.3%）。至少91.5%的患者最终视力至少达到20/40。
虽然本研究中患者的临床特征与视神经炎治疗试验非常相似，MS发病率高，大多数患者视力预后良好，对静脉注射类固醇反应良好，但仍有相当比例的特发性视神经炎病例可能需要通过更长时间的随访和重复血清生物标志物检测来更好地进行特征描述。
