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铁死亡策略在克服乳腺癌及不同癌细胞的肿瘤治疗耐药性中的应用。

Application of ferroptosis strategy to overcome tumor therapy resistance in breast and different cancer cells.

作者信息

Shahid Waniya, Iqbal Ahmar, Iqbal Iram, Mehmood Arshad, Jia Hongyan

机构信息

Department of General Surgery Sub Specialty Breast Surgery, Shanxi First Medical Hospital affiliated to Shanxi Medical University, Yingze District, 030000, Taiyuan, China.

Department of Pharmacology, Bahauddin Zakriya University Multan, Pakistan.

出版信息

Iran J Basic Med Sci. 2024;27(9):1085-1095. doi: 10.22038/IJBMS.2024.77465.16752.

DOI:10.22038/IJBMS.2024.77465.16752
PMID:39055871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11266745/
Abstract

This literature review emphasizes the innovative role of ferroptosis in cancer treatment. Ferroptosis is a kind of deliberate cell death that is characterized by the generation of lipid peroxides and needs the presence of iron. Ferroptosis is a controlled cell death process that adheres to certain rules and regulations. The inhibition of System Xc- and the involvement of GPX4 are two of the primary areas of exploration that are engaged in the process of ferroptosis. This review explores the treatments that are used to treat ferroptosis in a range of malignancies, with a particular focus on breast carcinoma. Attention is paid to certain pathways, such as the FSP1-independent regulation of glutathione, involvement of cholesterol, and the prominin 2-MVB/exosome-ferritin pathway. Ferroptosis plays a key role in resistance to tumor therapy.

摘要

本综述强调了铁死亡在癌症治疗中的创新作用。铁死亡是一种程序性细胞死亡，其特征是脂质过氧化物的产生且需要铁的存在。铁死亡是一个遵循特定规则的可控细胞死亡过程。抑制胱氨酸/谷氨酸反向转运体系统（System Xc-）和谷胱甘肽过氧化物酶4（GPX4）的参与是铁死亡过程中两个主要的探索领域。本综述探讨了用于治疗多种恶性肿瘤中铁死亡的方法，尤其关注乳腺癌。还关注了某些途径，如谷胱甘肽的FSP1非依赖性调节、胆固醇的参与以及prominin 2-多泡体/外泌体-铁蛋白途径。铁死亡在肿瘤治疗耐药中起关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fafd/11266745/39228d27069b/IJBMS-27-1085-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fafd/11266745/a0508f0cdbda/IJBMS-27-1085-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fafd/11266745/34b03c45cc4e/IJBMS-27-1085-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fafd/11266745/a5a7f00f6bce/IJBMS-27-1085-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fafd/11266745/39228d27069b/IJBMS-27-1085-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fafd/11266745/a0508f0cdbda/IJBMS-27-1085-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fafd/11266745/34b03c45cc4e/IJBMS-27-1085-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fafd/11266745/a5a7f00f6bce/IJBMS-27-1085-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fafd/11266745/39228d27069b/IJBMS-27-1085-g004.jpg

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本文引用的文献

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Ferroptosis Biology and Implication in Cancers.铁死亡生物学及其在癌症中的意义。
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2
Induction of ferroptosis by carnosic acid-mediated inactivation of Nrf2/HO-1 potentiates cisplatin responsiveness in OSCC cells.姜酚酸通过抑制 Nrf2/HO-1 发挥作用诱导铁死亡，增强口腔鳞状细胞癌细胞对顺铂的敏感性。
Mol Cell Probes. 2022 Aug;64:101821. doi: 10.1016/j.mcp.2022.101821. Epub 2022 Apr 29.
3
Ferroptosis at the intersection of lipid metabolism and cellular signaling.
铁死亡：脂质代谢与细胞信号交汇的新视角
Mol Cell. 2022 Jun 16;82(12):2215-2227. doi: 10.1016/j.molcel.2022.03.022. Epub 2022 Apr 6.
4
Targeting ferroptosis as a vulnerability in cancer.针对癌症中的铁死亡脆弱性。
Nat Rev Cancer. 2022 Jul;22(7):381-396. doi: 10.1038/s41568-022-00459-0. Epub 2022 Mar 25.
5
The Synergistic Reducing Drug Resistance Effect of Cisplatin and Ursolic Acid on Osteosarcoma through a Multistep Mechanism Involving Ferritinophagy.顺铂和熊果酸通过涉及铁蛋白自噬的多步骤机制协同增强骨肉瘤的耐药性。
Oxid Med Cell Longev. 2021 Dec 21;2021:5192271. doi: 10.1155/2021/5192271. eCollection 2021.
6
p53: A double-edged sword in tumor ferroptosis.p53：肿瘤铁死亡的双刃剑。
Pharmacol Res. 2022 Mar;177:106013. doi: 10.1016/j.phrs.2021.106013. Epub 2021 Nov 29.
7
Cancer: The role of iron and ferroptosis.癌症：铁与铁死亡的作用。
Int J Biochem Cell Biol. 2021 Dec;141:106094. doi: 10.1016/j.biocel.2021.106094. Epub 2021 Oct 8.
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Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy.脂质代谢调节RAS驱动型癌症中的氧化应激和铁死亡：关于癌症进展与治疗的观点
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