Baumgartner C, Delaleu B, Imbach P, Lüthy A, Odavic R, Brun del Re G, Bucher U, Forster H K, Hirt A, Wagner H P
IARC Sci Publ. 1985(60):435-40.
Reinfusion of undetected tumour cells is a possible cause of relapse after autologous bone-marrow transplantation. In this paper, a system for in-vitro purging of bone marrow is presented which involves the B-cell neoplasia-associated monoclonal antibody anti-Y 29/55 and complement. Five patients with Burkitt's lymphoma were transplanted with purged marrow, demonstrating the clinical feasibility of the method. The pretransplant regimen included vincristine 2 mg/m2, adriamycin 60 mg/m2, four doses of cyclophosphamide 45 mg/kg and total body irradiation with 6 Gy. Tumour control appears to be better in patients with purged bone marrow as compared to an earlier patient group with unpurged marrow.
未检测到的肿瘤细胞再输注是自体骨髓移植后复发的一个可能原因。本文介绍了一种体外净化骨髓的系统，该系统涉及与B细胞肿瘤相关的单克隆抗体抗-Y 29/55和补体。5例伯基特淋巴瘤患者接受了净化骨髓移植，证明了该方法的临床可行性。移植前的治疗方案包括长春新碱2mg/m²、阿霉素60mg/m²、四剂环磷酰胺45mg/kg以及6Gy的全身照射。与早期接受未净化骨髓移植的患者组相比，接受净化骨髓移植的患者肿瘤控制情况似乎更好。
