Láng Tamás, Dimén Diána, Oláh Szilvia, Puska Gina, Dobolyi Arpád
Laboratory of Neuromorphology, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Addiction and Neuroplasticity Laboratory, Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
iScience. 2024 Jun 19;27(7):110296. doi: 10.1016/j.isci.2024.110296. eCollection 2024 Jul 19.
The medial preoptic area (MPOA) has long been implicated in maternal and male sexual behavior. Modern neuroscience methods have begun to reveal the cellular networks responsible, while also implicating the MPOA in other social behaviors, affiliative social touch, and aggression. The social interactions rely on input from conspecifics whose most important modalities in rodents are olfaction and somatosensation. These inputs bypass the cerebral cortex to reach the MPOA to influence the social function. Hormonal inputs also directly act on MPOA neurons. In turn, the MPOA controls social responses via various projections for reward and motor output. The MPOA thus emerges as one of the major brain centers for instinctive social behavior. While key elements of MPOA circuits have been identified, a synthesis of these new data is now provided for further studies to reveal the mechanisms by which the area controls social interactions.
内侧视前区（MPOA）长期以来一直被认为与母性行为和雄性性行为有关。现代神经科学方法已开始揭示其中的细胞网络，同时也表明MPOA参与其他社会行为、亲和性社会接触和攻击行为。社会互动依赖于同种个体的输入，在啮齿动物中，这些输入最重要的方式是嗅觉和躯体感觉。这些输入绕过大脑皮层到达MPOA以影响社会功能。激素输入也直接作用于MPOA神经元。反过来，MPOA通过各种用于奖赏和运动输出的投射来控制社会反应。因此，MPOA成为本能社会行为的主要脑区之一。虽然已经确定了MPOA回路的关键要素，但现在提供这些新数据的综合信息，以供进一步研究揭示该区域控制社会互动的机制。
