在存在抗吞噬A组链球菌的情况下人吞噬细胞的功能未受损。
Unimpaired function of human phagocytes in the presence of phagocytosis-resistant group A streptococci.
作者信息
Manjula B N, Schmidt M L, Fischetti V A
出版信息
Infect Immun. 1985 Dec;50(3):610-3. doi: 10.1128/iai.50.3.610-613.1985.
Abstract
The resistance to phagocytosis of the group A streptococci has been attributed mainly to the presence of the surface antigen, M protein. In the present study, we addressed the question of whether the phagocytosis resistance of the group A streptococci is due to their ability to impair the function of the phagocytic cells. The results of these studies demonstrate that the presence of a large excess of a phagocytosis-resistant strain of streptococci does not significantly interfere with either the antibody-independent or the antibody-dependent phagocytosis of streptococci. Apparently, a phagocytosis-resistant strain of streptococci does not bring about a generalized deactivation of the phagocytic plasma membrane. This suggests that if the resistance of the group A streptococci is due to any deactivating influence at all on the phagocytic plasma membrane, it is likely to be confined to the contact area of the cocci with the phagocyte.
摘要
A组链球菌对吞噬作用的抵抗力主要归因于表面抗原M蛋白的存在。在本研究中，我们探讨了A组链球菌对吞噬作用的抵抗力是否源于其损害吞噬细胞功能的能力这一问题。这些研究结果表明，大量存在抗吞噬作用的链球菌菌株并不会显著干扰链球菌的非抗体依赖性或抗体依赖性吞噬作用。显然，抗吞噬作用的链球菌菌株不会导致吞噬细胞质膜的普遍失活。这表明，如果A组链球菌的抵抗力确实是由于对吞噬细胞质膜有任何失活影响的话，那么这种影响很可能局限于球菌与吞噬细胞的接触区域。
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