Can Ummugulsum, Akdu Sadinaz, Aktan Ahmet Hamdi
Department of Biochemistry, Konya City Hospital, Konya, Turkey.
Department of Biochemistry, Fethiye State Hospital, Muğla, Turkey.
Endocr Res. 2025 Feb;50(1):36-42. doi: 10.1080/07435800.2024.2384576. Epub 2024 Jul 26.
The hallmarks of Hashimoto's thyroiditis (HT) include the destruction of thyroid cells by leading to insulin resistance (IR), hypothyroidism, and metabolic abnormalities. Kisspeptin, spexin, and galanin control appetite and body weight (BW) to regulate metabolisms. Here, we sought to determine if galanin, kisspeptin, and spexin are linked to the pathophysiology of HT in euthyroid female individuals.
Forty-five women with HT and 45 healthy control women of the same age participated in the current study. The enzyme-linked immunosorbent assay (ELISA) method was used to measure the serum levels of galanin, spexin, and kisspeptin.
In comparison to the controls, HT patients had significantly higher levels of kisspeptin ( < 0.01), galanin ( < 0.01), anti-thyroid peroxidase (anti-TPO) ( < 0.001), anti-thyroglobulin (anti-Tg) ( < 0.001), and body mass index (BMI) ( < 0.05). The two groups were comparable in terms of spexin, free triiodothyronine-3 (fT3), fT4, thyroid-stimulating hormone (TSH) levels, and homeostatic model assessment for insulin resistance (HOMA-IR). Galanin and kisspeptin were seen to have a positive correlation ( < 0.01; = 0.786).
Euthyroid women with HT were found to have higher levels of kisspeptin and galanin. These results imply that kisspeptin and galanin may be linked to the pathogenesis of hypothyroidism, and as a result, we believe that these markers may be beneficial in the early detection and treatment of HT patients.
桥本甲状腺炎（HT）的特征包括甲状腺细胞破坏，进而导致胰岛素抵抗（IR）、甲状腺功能减退和代谢异常。 kisspeptin、spexin和甘丙肽可控制食欲和体重（BW）以调节新陈代谢。在此，我们试图确定甘丙肽、kisspeptin和spexin是否与甲状腺功能正常的女性个体中HT的病理生理学相关。
45名患有HT的女性和45名年龄相同的健康对照女性参与了本研究。采用酶联免疫吸附测定（ELISA）法测量血清中甘丙肽、spexin和kisspeptin的水平。
与对照组相比，HT患者的kisspeptin（<0.01）、甘丙肽（<0.01）、抗甲状腺过氧化物酶（抗TPO）（<0.001）、抗甲状腺球蛋白（抗Tg）（<0.001）和体重指数（BMI）（<0.05）水平显著更高。两组在spexin、游离三碘甲状腺原氨酸-3（fT3）、fT4、促甲状腺激素（TSH）水平以及胰岛素抵抗稳态模型评估（HOMA-IR）方面具有可比性。甘丙肽和kisspeptin呈正相关（<0.01；r=0.786）。
甲状腺功能正常的HT女性体内的kisspeptin和甘丙肽水平较高。这些结果表明，kisspeptin和甘丙肽可能与甲状腺功能减退的发病机制有关，因此，我们认为这些标志物可能有助于HT患者的早期检测和治疗。
