Cherchi A, Lai C, Angelino F, Trucco G, Caponnetto S, Mereto P E, Rosolen G, Manzoli U, Schiavoni G, Reale A
Int J Clin Pharmacol Ther Toxicol. 1985 Oct;23(10):569-72.
L-carnitine was studied in forty-four men with stable chronic angina in a multicenter, double-blind, randomized, placebo controlled crossover trial. A cycloergometer exercise test was performed after a 10-day wash-out with placebo and at the end of each 4-week treatment period with either L-carnitine (1 g twice daily) or placebo. The mean (+/- SD) exercise work load showed an increase after L-carnitine compared to placebo (102.73 +/- 22.23 and 97.05 +/- 22.77 watts respectively, p = 0.001), as did the watts to onset of angina (95.7 +/- 24.07 and 87.44 +/- 24.67, p = 0.000). On the contrary, the ST segment depression was reduced by L-carnitine compared to placebo both at the maximum work load (1.40 +/- 0.90 and 1.69 +/- 0.82 mm, p = 0.05) and at the maximum work load common to L-carnitine and placebo (1.24 +/- 0.90 and 1.66 +/- 0.79 mm, p = 0.005). 22.7% of the patients became free of angina with L-carnitine and 9.1% with placebo. Resting and exercise blood pressure, heart-rate and double product were unaffected by L-carnitine. 1 patient decided to discontinue the trial because of gastric pyrosis while taking the active drug. The results of this study show that treatment with L-carnitine increases exercise tolerance and reduces ECG indices of ischemia in stable effort-induced angina.
在一项多中心、双盲、随机、安慰剂对照的交叉试验中，对44名患有稳定型慢性心绞痛的男性进行了左旋肉碱的研究。在服用安慰剂进行10天洗脱期后，以及在每4周使用左旋肉碱（每日两次，每次1克）或安慰剂的治疗期结束时，进行了蹬车测力计运动试验。与安慰剂相比，左旋肉碱治疗后平均（±标准差）运动工作量有所增加（分别为102.73±22.23瓦和97.05±22.77瓦，p = 0.001），心绞痛发作时的瓦数也是如此（95.7±24.07和87.44±24.67，p = 0.000）。相反，与安慰剂相比，左旋肉碱在最大工作量时（1.40±0.90和1.69±0.82毫米，p = 0.05）以及在左旋肉碱和安慰剂共同的最大工作量时（1.24±0.90和1.66±0.79毫米，p = 0.005），均使ST段压低减少。22.7%的患者使用左旋肉碱后心绞痛消失，使用安慰剂的为9.1%。静息和运动时的血压、心率及双乘积不受左旋肉碱影响。1名患者在服用活性药物时因胃灼热决定退出试验。本研究结果表明，左旋肉碱治疗可提高稳定型劳力性心绞痛患者的运动耐量并降低缺血的心电图指标。
