Heilmann Mareike, Heilmann Ingo
Department of Plant Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Charles-Tanford Protein Science Center, 06120 Halle (Saale), Germany.
Plant Physiol. 2025 Feb 7;197(2). doi: 10.1093/plphys/kiae393.
In eukaryotes, a small subset of membrane lipids, the phosphoinositides (PIs), exert regulatory effects on membrane-associated processes with profound impact on the organism, and PIs are relevant also for the physiology and development of plants. The PI, phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) has emerged as an important regulatory player in plants, and in recent years this lipid has received substantial attention. This Update Review focuses on our current understanding of how PtdIns(4,5)P2 exerts its regulatory functions, how biosynthesis and degradation of this important regulatory lipid are controlled, and how PtdIns(4,5)P2 is linked to upstream and downstream elements within plant signalling networks.
在真核生物中，一小部分膜脂，即磷酸肌醇（PIs），对与膜相关的过程发挥调节作用，对生物体有深远影响，并且PIs对植物的生理和发育也很重要。磷脂酰肌醇4,5-二磷酸（PtdIns(4,5)P2）已成为植物中一种重要的调节因子，近年来这种脂质受到了广泛关注。本综述聚焦于我们目前对PtdIns(4,5)P2如何发挥其调节功能、这种重要调节脂质的生物合成和降解如何受到控制，以及PtdIns(4,5)P2如何与植物信号网络中的上游和下游元件相联系的理解。
