Laxalt Ana M, van Hooren Max, Munnik Teun
Instituto de Investigaciones Biológicas, IIB-CONICET, Universidad Nacional de Mar del Plata, Argentina.
Plant Cell Biologie, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
Plant Physiol. 2025 Feb 7;197(2). doi: 10.1093/plphys/kiae534.
Phosphoinositide-specific phospholipase C (PI-PLC) signaling is involved in various plant stress and developmental responses. Though several aspects of this lipid signaling pathway are conserved within animals and plants, clear differences have also emerged. While animal PLC signaling is characterized by the hydrolysis of PIP2 and production of IP3 and DAG as second messengers to activate Ca2+ and PKC signaling, plant PI-PLCs seem to predominantly use PIP as substrate and convert IP2 and DAG into inositolpolyphosphates and phosphatidic acid (PA) as plant second messengers. Sequencing of multiple plant genomes confirmed that plant PLC signaling evolved differently from animals, lacking homologs of the IP3 gated-Ca2+ channel, PKC and TRP channels, and with PLC enzymes resembling the PLCζ subfamily, which lacks the conserved PH domain that binds PIP2. With emerging tools in plant molecular biology, data analyses, and advanced imaging, plant PLC signaling is ready to gain momentum.
磷脂酰肌醇特异性磷脂酶C（PI-PLC）信号传导参与植物的各种应激反应和发育过程。尽管该脂质信号通路在动植物中有几个方面是保守的，但也出现了明显的差异。动物的PLC信号传导以PIP2水解产生IP3和DAG作为第二信使来激活Ca2+和PKC信号为特征，而植物PI-PLC似乎主要以PIP为底物，将IP2和DAG转化为肌醇多磷酸和磷脂酸（PA）作为植物第二信使。多个植物基因组的测序证实，植物PLC信号传导与动物的进化方式不同，缺乏IP3门控Ca2+通道、PKC和TRP通道的同源物，并且其PLC酶类似于PLCζ亚家族，该亚家族缺乏结合PIP2的保守PH结构域。随着植物分子生物学、数据分析和先进成像技术的不断涌现，植物PLC信号传导即将迎来发展契机。
