Department of Biology, Indiana University, Bloomington, IN 47401, USA.
Cells. 2024 Jul 14;13(14):1192. doi: 10.3390/cells13141192.
Studies on numerous species have demonstrated strikingly conserved mechanisms that determine the aging process, from yeasts to worms, flies, zebrafish, mice, and humans. The fruit fly is an excellent model organism for studying the biological basis of normal aging and etiology of age-related diseases. Since its inception in 1967, the Bloomington Drosophila Stock Center (BDSC) has grown into the largest collection of documented strains (currently > 91,000). This paper aims to briefly review conserved mechanisms of aging and provides a guide to help users understand the organization of stock listings on the BDSC website and familiarize themselves with the search functions on BDSC and FlyBase, with an emphasis on using genes in conserved pathways as examples to find stocks for aging studies.
对从酵母到蠕虫、苍蝇、斑马鱼、老鼠和人类等众多物种的研究表明，决定衰老过程的机制惊人地保守。果蝇是研究正常衰老的生物学基础和与年龄相关疾病病因的极佳模式生物。自 1967 年成立以来，Bloomington Drosophila Stock Center（BDSC）已发展成为文档记录菌株数量最多的收藏中心（目前>91000 个）。本文旨在简要综述衰老的保守机制，并提供一个指南，帮助用户了解 BDSC 网站上的库存清单的组织，并熟悉 BDSC 和 FlyBase 的搜索功能，重点是使用保守途径中的基因作为示例来寻找用于衰老研究的品系。
