Monaco Martina, Trebesova Hanna, Grilli Massimo
Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, Italy.
Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 16148 Genoa, Italy.
Curr Issues Mol Biol. 2024 Jul 2;46(7):6820-6835. doi: 10.3390/cimb46070407.
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases on a global scale. Historically, this pathology has been linked to cholinergic transmission, and despite the scarcity of effective therapies, numerous alternative processes and targets have been proposed as potential avenues for comprehending this complex illness. Nevertheless, the fundamental pathophysiological mechanisms underpinning AD remain largely enigmatic, with a growing body of evidence advocating for the significance of muscarinic receptors in modulating the brain's capacity to adapt and generate new memories. This review summarizes the current state of the art in the field of muscarinic receptors' involvement in AD. A specific key factor was the relationship between comorbidity and the emergence of new mechanisms.
阿尔茨海默病（AD）是全球最常见的神经退行性疾病之一。从历史上看，这种病理状况一直与胆碱能传递有关，尽管有效疗法匮乏，但人们已经提出了许多替代过程和靶点，作为理解这种复杂疾病的潜在途径。然而，AD的基本病理生理机制在很大程度上仍然是个谜，越来越多的证据表明毒蕈碱受体在调节大脑适应和产生新记忆的能力方面具有重要意义。本综述总结了毒蕈碱受体参与AD领域的当前研究现状。一个特定的关键因素是合并症与新机制出现之间的关系。
