Daneshwar Datesh, Lee Yemin, Nordin Abid
Urology Clinic, Prince Court Medical Centre, 39, Jalan Kia Peng, Kuala Lumpur 50450, Malaysia.
MedCentral Consulting, International Youth Centre, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia.
Diseases. 2024 Jul 15;12(7):157. doi: 10.3390/diseases12070157.
Coronavirus disease 2019 (COVID-19), a highly contagious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a global health threat. The virus enters host cells by binding with angiotensin-converting enzyme 2 (ACE2), which is then facilitated by the protease activity of transmembrane serine protease 2 (TMPRSS2). It triggers a cytokine storm that eventually leads to cell apoptosis, tissue damage, and organ failure. Therefore, any organs in the human body that have both receptors are highly susceptible to COVID-19 infection, potentially resulting in multiple-organ failure. The prostate has been reported to express high levels of ACE2 and TMPRSS2. While there are limited studies regarding the association between COVID-19 and prostatitis, the possibility that SARS-CoV-2 could cause prostatitis cannot be denied. Thus, through this review, a better insight into the associations of SAR-CoV-2 can be provided.
2019冠状病毒病（COVID-19）是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的一种高度传染性病毒性疾病，对全球健康构成威胁。该病毒通过与血管紧张素转换酶2（ACE2）结合进入宿主细胞，随后跨膜丝氨酸蛋白酶2（TMPRSS2）的蛋白酶活性促进其进入。它引发细胞因子风暴，最终导致细胞凋亡、组织损伤和器官衰竭。因此，人体中任何同时具有这两种受体的器官都极易受到COVID-19感染，可能导致多器官衰竭。据报道，前列腺表达高水平的ACE2和TMPRSS2。虽然关于COVID-19与前列腺炎之间关联的研究有限，但不能否认SARS-CoV-2可能导致前列腺炎的可能性。因此，通过本综述，可以更好地了解SARS-CoV-2的关联。
