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羟基磷灰石和羟基磷灰石-钛植入物骨整合的比较分析：一项体内兔模型研究

Comparative Analysis of Osteointegration in Hydroxyapatite and Hydroxyapatite-Titanium Implants: An In Vivo Rabbit Model Study.

作者信息

Văruț Renata Maria, Rotaru Luciana Teodora, Truicu Flavius Nicușor, Singer Cristina Elena, Iulian-Nicolae Iliescu, Popescu Alin Iulian Silviu, Popescu Cristina, Teisanu Cristina, Sima Gabriela, Nicolaescu Oana Elena

机构信息

Research Methodology Department, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Emergency Medicine and First Aid Department, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

出版信息

J Funct Biomater. 2024 Jun 29;15(7):181. doi: 10.3390/jfb15070181.

DOI:10.3390/jfb15070181
PMID:39057303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11278386/
Abstract

The study evaluates the osteointegration of hydroxyapatite (HAp) and hydroxyapatite-titanium (HApTi) biocomposites implanted in the femurs of rabbits. The biocomposites were fabricated using powder metallurgy and subjected to a two-step sintering process. Scanning electron microscopy (SEM) was employed to analyze the morphology, while mesenchymal stem cells were cultured to assess cytotoxicity and proliferation. In vivo experiments involved the implantation of HAp in the left femur and HApTi in the right femur of twenty New Zealand white rabbits. Computed tomography (CT) scans, histological, immunohistochemical, and histomorphometric analyses were performed to assess bone density and osteoblast activity. Results demonstrated that HApTi implants showed superior osteointegration, with higher peri-implant bone density and increased osteoblast count compared to HAp implants. This study concluded that HApTi biocomposites have potential for enhanced bone healing and stability in orthopedic applications.

摘要

该研究评估了植入兔股骨的羟基磷灰石（HAp）和羟基磷灰石-钛（HApTi）生物复合材料的骨整合情况。这些生物复合材料采用粉末冶金法制备，并经过两步烧结工艺。使用扫描电子显微镜（SEM）分析其形态，同时培养间充质干细胞以评估细胞毒性和增殖情况。体内实验包括将HAp植入20只新西兰白兔的左股骨，将HApTi植入右股骨。进行计算机断层扫描（CT）、组织学、免疫组织化学和组织形态计量学分析以评估骨密度和成骨细胞活性。结果表明，与HAp植入物相比，HApTi植入物显示出更好的骨整合，植入物周围骨密度更高，成骨细胞数量增加。本研究得出结论，HApTi生物复合材料在骨科应用中具有增强骨愈合和稳定性的潜力。

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