Huang Yi-Huei, Wu I-Ting, Chen Chun-Cheng, Ding Shinn-Jyh
School of Dentistry, Chung Shan Medical University, Taichung City 402, Taiwan.
School of Dentistry, China Medical University, Taichung City 404, Taiwan.
J Funct Biomater. 2024 Jul 5;15(7):187. doi: 10.3390/jfb15070187.
Calcium silicate (CaSi) bone cement with antibacterial and osteogenic properties has attracted significant interest. However, there is a need to develop a variety of new premixed bone cement to meet the clinical requirements of fast setting time, ease of handling, and efficient antibacterial properties. In this study, different volume ratios of polyethylene glycol (PEG) and lactic acid liquids were added to calcium silicate, and the effects of varying liquid-to-powder ratios (L/P) were examined. This study assessed the physicochemical properties, cytotoxicity, and antibacterial activity against and of this premixed cement. The results from the experiments indicated that lactic acid significantly reduced the setting time of the CaSi-based cement and enhanced its mechanical strength. Furthermore, the appropriate concentration of lactic acid and matching L/P ratio improved its washout resistance. The cell viability of all premixed cement was found to be over 80%. The premixed cement containing PEG and lactic acid exhibited superior antibacterial properties compared to the CaSi control. Based on its setting time, washout resistance, and antibacterial activity, a premixed cement with a liquid phase of 80% PEG and 20% lactic acid at an L/P ratio of 0.4 appeared promising for use in dental and orthopedic practice.
具有抗菌和成骨特性的硅酸钙（CaSi）骨水泥引起了广泛关注。然而，需要开发多种新型预混骨水泥，以满足快速凝固时间、易于操作和高效抗菌性能等临床需求。在本研究中，将不同体积比的聚乙二醇（PEG）和乳酸液体添加到硅酸钙中，并研究了不同液粉比（L/P）的影响。本研究评估了这种预混水泥的物理化学性质、细胞毒性以及对[具体菌种1]和[具体菌种2]的抗菌活性。实验结果表明，乳酸显著缩短了CaSi基水泥的凝固时间并增强了其机械强度。此外，适当浓度的乳酸和匹配的L/P比提高了其抗冲洗性。所有预混水泥的细胞活力均超过80%。与CaSi对照相比，含有PEG和乳酸的预混水泥表现出优异的抗菌性能。基于其凝固时间、抗冲洗性和抗菌活性，一种液粉比为0.4、液相为80%PEG和20%乳酸的预混水泥在牙科和骨科实践中显示出应用前景。
