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多糖复合微胶囊对 模拟胃肠道消化和热处理过程中生存的保护作用。

Protective Effects of Polysaccharide Composite Microcapsules on the Survival of during Simulated Gastrointestinal Digestion and Heat Treatment.

机构信息

Engineering Technology Innovation Center for the Development and Utilization of Marine Living Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China.

Xiamen Ocean Vocational College, Xiamen 361100, China.

出版信息

Mar Drugs. 2024 Jun 30;22(7):308. doi: 10.3390/md22070308.

DOI:10.3390/md22070308
PMID:39057417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11277663/
Abstract

To improve probiotics' survivability during gastrointestinal digestion and heat treatment, was microencapsulated by spray-drying using polysaccharide/sodium caseinate/gelatin (LJP/SC/GE) composites. Thermogravimetry and differential scanning calorimetry results revealed that the denaturation of LJP/SC/GE microcapsules requires higher thermal energy than that of SC/GE microcapsules, and the addition of LJP may improve thermal stability. Zeta potential measurements indicated that, at low pH of the gastric fluid, the negatively charged LJP attracted the positively charged SC/GE, helping to maintain an intact microstructure without disintegration. The encapsulation efficiency of -loaded LJP/SC/GE microcapsules reached about 93.4%, and the survival rate was 46.9% in simulated gastric fluid (SGF) for 2 h and 96.0% in simulated intestinal fluid (SIF) for 2 h. In vitro release experiments showed that the LJP/SC/GE microcapsules could protect the viability of in SGF and release probiotics slowly in SIF. The cell survival of LJP/SC/GE microcapsules was significantly improved during the heat treatment compared to SC/GE microcapsules and free cells. LJP/SC/GE microcapsules can increase the survival of by maintaining the lactate dehydrogenase and Na-K-ATPase activity. Overall, this study demonstrates the great potential of LJP/SC/GE microcapsules to protect and deliver probiotics in food and pharmaceutical systems.

摘要

为了提高益生菌在胃肠道消化和热处理过程中的存活率，采用多糖/酪蛋白酸钠/明胶（LJP/SC/GE）复合材料进行喷雾干燥微胶囊化。热重分析和差示扫描量热法结果表明，LJP/SC/GE 微胶囊的变性需要比 SC/GE 微胶囊更高的热能，并且 LJP 的添加可能提高热稳定性。Zeta 电位测量表明，在低 pH 的胃液中，带负电荷的 LJP 吸引带正电荷的 SC/GE，有助于保持完整的微结构而不崩解。-负载的 LJP/SC/GE 微胶囊的包封效率约为 93.4%，在模拟胃液（SGF）中 2 h 的存活率为 46.9%，在模拟肠液（SIF）中 2 h 的存活率为 96.0%。体外释放实验表明，LJP/SC/GE 微胶囊可以在 SGF 中保护 的活力，并在 SIF 中缓慢释放益生菌。与 SC/GE 微胶囊和游离细胞相比，LJP/SC/GE 微胶囊在热处理过程中可以显著提高 的存活率。LJP/SC/GE 微胶囊可以通过维持乳酸脱氢酶和 Na-K-ATP 酶的活性来提高 的存活率。总的来说，这项研究表明 LJP/SC/GE 微胶囊在食品和制药系统中保护和输送益生菌具有巨大的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/67369ec0051c/marinedrugs-22-00308-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/c4a071aa087e/marinedrugs-22-00308-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/7bd38187c273/marinedrugs-22-00308-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/4c1d6dc08caa/marinedrugs-22-00308-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/9bbf40b5040c/marinedrugs-22-00308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/31497d656587/marinedrugs-22-00308-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/50d82a5d99c1/marinedrugs-22-00308-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/acc9b99df6b6/marinedrugs-22-00308-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/5aade2dfecb7/marinedrugs-22-00308-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/67369ec0051c/marinedrugs-22-00308-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/c4a071aa087e/marinedrugs-22-00308-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/7bd38187c273/marinedrugs-22-00308-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/4c1d6dc08caa/marinedrugs-22-00308-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/9bbf40b5040c/marinedrugs-22-00308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/31497d656587/marinedrugs-22-00308-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/50d82a5d99c1/marinedrugs-22-00308-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/acc9b99df6b6/marinedrugs-22-00308-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/5aade2dfecb7/marinedrugs-22-00308-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d222/11277663/67369ec0051c/marinedrugs-22-00308-g009.jpg

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Combination of Lycium barbarum L. and Laminaria japonica polysaccharides as a highly efficient prebiotic: Optimal screening and complementary regulation of gut probiotics and their metabolites.
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