N末端B型利钠肽原水平在射血分数保留的心力衰竭诊断和治疗中的作用——这并不总是一场捉迷藏游戏。
The Role of NT-proBNP Levels in the Diagnosis and Treatment of Heart Failure with Preserved Ejection Fraction-It Is Not Always a Hide-and-Seek Game.
作者信息
Chrysohoou Christina, Konstantinou Konstantinos, Tsioufis Kostas
机构信息
1st Cardiology Clinic, Hippokration Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
出版信息
J Cardiovasc Dev Dis. 2024 Jul 16;11(7):225. doi: 10.3390/jcdd11070225.
Abstract
Although heart failure with preserved ejection fraction (HFpEF) has become the predominant heart failure subtype, it remains clinically under-recognized. This has been attributed to the complex pathophysiological mechanisms that accompany individuals with several co-morbidities and symptoms and signs of HFpEF. Natriuretic peptides have been recognized as playing an important role in the diagnosis and monitoring of patients with heart failure with reduced ejection fraction (HFrEF), but their role in HFpEF remains controversial, driven by the different pathophysiological characteristics of these patients. The type of diet consumed has shown various modifying effects on plasma levels of NPs, irrespective of pharmacological treatment.
摘要
尽管射血分数保留的心力衰竭（HFpEF）已成为主要的心力衰竭亚型，但在临床上仍未得到充分认识。这归因于伴有多种合并症以及HFpEF症状和体征的个体所伴随的复杂病理生理机制。利钠肽已被认为在射血分数降低的心力衰竭（HFrEF）患者的诊断和监测中发挥重要作用，但由于这些患者不同的病理生理特征，其在HFpEF中的作用仍存在争议。无论药物治疗如何，所食用的饮食类型已显示出对利钠肽血浆水平有多种调节作用。
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2
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3
2024 update in heart failure.2024年心力衰竭治疗进展
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