Mentzel Luise Antonia, Shahidi Parham, Blazek Stephan, Sulimov Dmitry, Thiele Holger, Fengler Karl
Department of Cardiology, Heart Center Leipzig at University of Leipzig, Struempellstr. 39, 04289 Leipzig, Germany.
J Cardiovasc Dev Dis. 2024 Jul 22;11(7):228. doi: 10.3390/jcdd11070228.
For patients with high-risk pulmonary artery embolism (PE), catheter-directed therapies pose a viable alternative treatment option to systemic thrombolysis or anticoagulation. Right now, there are multiple devices available which have been proven to be safe and effective in lower-risk settings. There is, however, little data comparing their efficacies in high-risk PE.
We performed a retrospective, single-center study on patients with high-risk PE undergoing catheter interventional treatment. Patients receiving large-bore catheter thrombectomy were compared to patients receiving alternative treatment forms.
Of the 20 patients included, 9 received large-bore thrombectomy, and 11 received alternative interventional treatments. While the baseline characteristics were comparable between the two groups, periprocedural and in-hospital mortality tended to be significantly lower with large-bore thrombectomy when compared to other treatment forms (0 vs. 55% and 33 vs. 82%, = 0.07 and 0.01, respectively).
In this small, retrospective study, large-bore thrombectomy was associated with lower mortality as compared to alternative treatment forms. Future prospective research is needed to corroborate these findings.
对于高危肺动脉栓塞（PE）患者，导管定向治疗是全身溶栓或抗凝治疗的一种可行替代治疗选择。目前，有多种设备已被证明在低风险情况下是安全有效的。然而，比较它们在高危PE中疗效的数据很少。
我们对接受导管介入治疗的高危PE患者进行了一项回顾性单中心研究。将接受大口径导管血栓切除术的患者与接受其他治疗形式的患者进行比较。
纳入的20例患者中，9例接受了大口径血栓切除术，11例接受了其他介入治疗。虽然两组的基线特征具有可比性，但与其他治疗形式相比，大口径血栓切除术的围手术期和住院死亡率明显较低（分别为0%对55%和33%对82%，P值分别为0.07和0.01）。
在这项小型回顾性研究中，与其他治疗形式相比，大口径血栓切除术与较低的死亡率相关。需要未来的前瞻性研究来证实这些发现。
