妊娠期糖尿病女性中DNA甲基化与婴儿出生体重的关联
Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes.
作者信息
Saucedo Renata, Ferreira-Hermosillo Aldo, Robledo-Clemente Magalhi, Díaz-Velázquez Mary Flor, Valencia-Ortega Jorge
机构信息
Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Hospital de Gineco Obstetricia 3, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico.
出版信息
Metabolites. 2024 Jun 27;14(7):361. doi: 10.3390/metabo14070361.
Offspring exposed to gestational diabetes mellitus (GDM) exhibit greater adiposity at birth. This early-life phenotype may increase offspring risk of developing obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease later in life. Infants born to women with GDM have a dysregulation of several hormones, cytokines, and growth factors related to fetal fat mass growth. One of the molecular mechanisms of GDM influencing these factors is epigenetic alterations, such as DNA methylation (DNAm). This review will examine the role of DNAm as a potential biomarker for monitoring fetal growth during pregnancy in women with GDM. This information is relevant since it may provide useful new biomarkers for the diagnosis, prognosis, and treatment of fetal growth and its later-life health consequences.
暴露于妊娠期糖尿病（GDM）的后代在出生时表现出更高的肥胖程度。这种早期生活表型可能会增加后代日后患肥胖症、代谢综合征、2型糖尿病和心血管疾病的风险。患有GDM的女性所生的婴儿，与胎儿脂肪量增长相关的几种激素、细胞因子和生长因子存在失调。GDM影响这些因素的分子机制之一是表观遗传改变，如DNA甲基化（DNAm）。本综述将探讨DNAm作为监测GDM孕妇孕期胎儿生长的潜在生物标志物的作用。这些信息具有相关性，因为它可能为胎儿生长及其后期健康后果的诊断、预后和治疗提供有用的新生物标志物。
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