Pelpolage Samanthi Wathsala, Sasaki Rie, Shimada Kenichiro, Nagura Taizo, Uchino Hirokatsu, Han Kyu-Ho, Fukushima Michihiro
Department of Life and Food Sciences, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro 080-8555, Hokkaido, Japan.
Research Center, Nippon Beet Sugar Mfg., Co., Ltd., Obihiro 080-0831, Hokkaido, Japan.
Metabolites. 2024 Jul 18;14(7):390. doi: 10.3390/metabo14070390.
Supplementation of betaine is associated with improved cardiac health, potentially due to its function in re-methylation of homocysteine, an independent risk factor for cardiovascular diseases. We investigated the effects of oral betaine supplementation on blood pressure homeostasis in spontaneously hypertensive (SHR) rats and Wistar Kyoto (WKY) rats in an 8 week-feeding trial with control (SHR-con and WKY-con) and 1% betaine supplemented (SHR-b and WKY-b) diets. Systolic, diastolic, and mean blood pressure in the SHR-b group were significantly lower at week 8 ( = 0.013, = 0.011, = 0.010, respectively). Furthermore, serum nitric oxide (NO) levels were significantly ( < 0.05) improved in the WKY-b and SHR-b groups, suggesting a healthy endothelial function. Additionally, the serum angiotensin I converting enzyme level in SHR-b rats was also significantly lowered, which may have been another reason for lower blood pressure. A significantly higher non-HDL level in the SHR-b group might reflect enhanced lipid secretion into the circulation in the form of very-low-density lipoprotein (VLDL). Betaine is known for its effect on the synthesis of phosphatidylcholine, a key component of VLDL. However, the long-term net outcomes of both blood pressure lowering and serum lipid increment should be further studied.
补充甜菜碱与改善心脏健康有关，这可能是由于其在同型半胱氨酸再甲基化中的作用，同型半胱氨酸是心血管疾病的一个独立危险因素。在一项为期8周的喂养试验中，我们研究了口服补充甜菜碱对自发性高血压（SHR）大鼠和Wistar Kyoto（WKY）大鼠血压稳态的影响，试验采用对照（SHR-con和WKY-con）和补充1%甜菜碱（SHR-b和WKY-b）的饮食。SHR-b组在第8周时收缩压、舒张压和平均血压显著降低（分别为P = 0.013、P = 0.011、P = 0.010）。此外，WKY-b组和SHR-b组的血清一氧化氮（NO）水平显著改善（P < 0.05），表明内皮功能健康。此外，SHR-b大鼠的血清血管紧张素I转换酶水平也显著降低，这可能是血压降低的另一个原因。SHR-b组显著更高的非高密度脂蛋白水平可能反映了以极低密度脂蛋白（VLDL）形式增强的脂质分泌进入循环。甜菜碱以其对磷脂酰胆碱（VLDL的关键成分）合成的影响而闻名。然而，血压降低和血清脂质增加的长期净结果仍需进一步研究。
