Yuan Deqiang, Chu Jiapeng, Lin Hao, Zhu Guoqi, Qian Jun, Yu Yunan, Yao Tongqing, Ping Fan, Chen Fei, Liu Xuebo
Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Front Cardiovasc Med. 2023 Jan 16;9:1109445. doi: 10.3389/fcvm.2022.1109445. eCollection 2022.
Homocysteine (Hcy) is an intermediate amino acid formed during the conversion from methionine to cysteine. When the fasting plasma Hcy level is higher than 15 μmol/L, it is considered as hyperhomocysteinemia (HHcy). The vascular endothelium is an important barrier to vascular homeostasis, and its impairment is the initiation of atherosclerosis (AS). HHcy is an important risk factor for AS, which can promote the development of AS and the occurrence of cardiovascular events, and Hcy damage to the endothelium is considered to play a very important role. However, the mechanism by which Hcy damages the endothelium is still not fully understood. This review summarizes the mechanism of Hcy-induced endothelial injury and the treatment methods to alleviate the Hcy induced endothelial dysfunction, in order to provide new thoughts for the diagnosis and treatment of Hcy-induced endothelial injury and subsequent AS-related diseases.
同型半胱氨酸（Hcy）是蛋氨酸转化为半胱氨酸过程中形成的一种中间氨基酸。当空腹血浆Hcy水平高于15μmol/L时，被认为是高同型半胱氨酸血症（HHcy）。血管内皮是维持血管稳态的重要屏障，其损伤是动脉粥样硬化（AS）的起始环节。HHcy是AS的重要危险因素，可促进AS的发展和心血管事件的发生，且Hcy对内皮的损伤被认为起非常重要的作用。然而，Hcy损伤内皮的机制仍未完全阐明。本文综述了Hcy诱导内皮损伤的机制以及减轻Hcy诱导的内皮功能障碍的治疗方法，以期为Hcy诱导的内皮损伤及后续AS相关疾病的诊治提供新思路。
