Division of Nephrology, Department of Medicine, The University of Mississippi Medical Center, Jackson, MS 39216, USA.
Renal Research Institute, New York, NY 10065, USA.
Toxins (Basel). 2024 Jun 28;16(7):298. doi: 10.3390/toxins16070298.
Individuals afflicted with advanced kidney dysfunction who require dialysis for medical management exhibit different degrees of native kidney function, called residual kidney function (RKF), ranging from nil to appreciable levels. The primary focus of this manuscript is to delve into the concept of RKF, a pivotal yet under-represented topic in nephrology. To begin, we unpack the definition and intrinsic nature of RKF. We then juxtapose the efficiency of RKF against that of hemodialysis in preserving homeostatic equilibrium and facilitating physiological functions. Given the complex interplay of RKF and overall patient health, we shed light on the extent of its influence on patient outcomes, particularly in those living with advanced kidney dysfunction and on dialysis. This manuscript subsequently presents methodologies and measures to assess RKF, concluding with the potential benefits of targeted interventions aimed at preserving RKF.
患有晚期肾功能衰竭并需要透析治疗的患者表现出不同程度的原生肾功能，称为残余肾功能（RKF），范围从几乎没有到相当可观。本文的主要重点是深入探讨 RKF 的概念，这是肾脏病学中一个重要但未得到充分重视的话题。首先，我们剖析 RKF 的定义和内在性质。然后，我们将 RKF 的效率与血液透析在维持体内平衡和促进生理功能方面的效率进行对比。鉴于 RKF 与整体患者健康之间的复杂相互作用，我们阐明了它对患者结局的影响程度，特别是在那些患有晚期肾功能衰竭并接受透析治疗的患者中。本文随后介绍了评估 RKF 的方法和措施，最后介绍了旨在保护 RKF 的靶向干预措施的潜在益处。
