Stefanetti Valentina, Passamonti Fabrizio, Rampacci Elisa
Department of Human Science and Promotion of Quality Life, San Raffaele Telematic University, 00166 Rome, Italy.
Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
Vet Sci. 2024 Jul 11;11(7):311. doi: 10.3390/vetsci11070311.
The treatment of dermato-pathogenic spp., particularly , in companion animals presents significant challenges due to rising antimicrobial resistance. This review explores innovative strategies to combat these infections. We examined novel antimicrobials and the repurposing of existing drugs to enhance their efficacy against resistant strains. Additionally, we evaluate the potential of natural products, nanomaterials, and skin antiseptics as alternative treatments. The review also investigates the use of antimicrobial peptides and bacteriophages, highlighting their targeted action against staphylococcal pathogens. Furthermore, the role of adjuvants in antibiotic treatments, such as antimicrobial resistance breakers, is discussed, emphasizing their ability to enhance therapeutic outcomes. Our analysis underscores the importance of a multifaceted approach in developing effective antimicrobial strategies for companion animals, aiming to mitigate resistance and improve clinical management of staphylococcal skin infections.
由于抗菌药物耐药性不断上升，治疗伴侣动物的皮肤致病性物种，尤其是[此处原文缺失具体物种]面临着重大挑战。本综述探讨了对抗这些感染的创新策略。我们研究了新型抗菌药物以及现有药物的重新利用，以提高它们对耐药菌株的疗效。此外，我们评估了天然产物、纳米材料和皮肤防腐剂作为替代治疗方法的潜力。该综述还研究了抗菌肽和噬菌体的使用，强调了它们对葡萄球菌病原体的靶向作用。此外，还讨论了佐剂在抗生素治疗中的作用，如抗菌耐药性突破剂，强调了它们提高治疗效果的能力。我们的分析强调了采取多方面方法制定有效的伴侣动物抗菌策略的重要性，旨在减轻耐药性并改善葡萄球菌皮肤感染的临床管理。
