Wang Jun, Yu Ying, Jiang Jiayi, Li Bolin, Xie Weimin, Li Gezi, Song Huanjie, Zhai Wanying, Li Ye
School of Resource and Environmental Engineering, Wuhan University of Technology, Wuhan 430070, China.
Wuhan Lingang Economic and Technological Development Zone Service Industry Development Investment Group Co., Ltd., Wuhan 430040, China.
Toxics. 2024 Jul 14;12(7):507. doi: 10.3390/toxics12070507.
In contemporary society, the improper use of antibiotics leads to their persistent presence in the ecological environment. Due to the diverse physical and chemical properties of antibiotics, their spatial and temporal distribution in the environment varies. Moreover, antibiotics can stimulate the emergence of antibiotic resistance genes (ARGs), which complicates the monitoring and regulation of antibiotics and poses a significant threat to both aquatic and terrestrial environments. This study investigated the distribution of 15 antibiotics and 11 typical ARGs across four categories at 19 sites of drinking water sources in Wuhan, China. The findings revealed that the concentration of antibiotics during the dry season (nd61,883 ng/L) was significantly higher compared to both the normal water season (nd49,883 ng/L) and the wet season (nd~28,686 ng/L). Sulfamethoxazole (SMX), sulfamethoxazole (SMD), sulfadiazine (SD), and roxithromycin (RTM) were the predominant antibiotics in the target water environments. The study indicated that most of the antibiotics analyzed posed little to no risk to aquatic organisms. The primary ARGs detected in the surface water of the study area were , , and . Furthermore, some ARGs showed a negative correlation with their respective antibiotics. Additional research is necessary to evaluate the impact of these emerging pollutants (antibiotics and ARGs) on the safety of high-quality drinking water for residents in Wuhan City.
在当代社会，抗生素的不当使用导致其持续存在于生态环境中。由于抗生素具有多样的物理和化学性质，它们在环境中的时空分布各不相同。此外，抗生素可刺激抗生素抗性基因（ARGs）的出现，这使得抗生素的监测和监管变得复杂，并对水生和陆地环境都构成重大威胁。本研究调查了中国武汉市19个饮用水源地中15种抗生素和4类11种典型ARGs的分布情况。研究结果显示，枯水期抗生素浓度（nd61,883 ng/L）显著高于平水期（nd49,883 ng/L）和丰水期（nd~28,686 ng/L）。磺胺甲恶唑（SMX）、磺胺间二甲氧嘧啶（SMD）、磺胺嘧啶（SD）和罗红霉素（RTM）是目标水环境中的主要抗生素。该研究表明，所分析的大多数抗生素对水生生物几乎没有风险。研究区域地表水中检测到的主要ARGs为 、 和 。此外，一些ARGs与其各自的抗生素呈负相关。有必要开展进一步研究，以评估这些新兴污染物（抗生素和ARGs）对武汉市居民优质饮用水安全的影响。
