Meque Ivete, Herrera Nicole, Gill Michelle M, Guilaze Rui, Nhangave Amancio, Mussá Jaciara, Bhatt Nilesh, Bonou Mahoudo, Greenberg Lauren
Elizabeth Glaser Pediatric AIDS Foundation, Maputo, Mozambique.
Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC 20005, USA.
Trop Med Infect Dis. 2024 Jun 26;9(7):141. doi: 10.3390/tropicalmed9070141.
With the increase in uptake of multi-month antiretroviral therapy dispensing (MMD) for children, little is known about consistency of MMD receipt over time and its association with virological outcomes. This analysis aims to assess the uptake of 3-month MMD among children, consistent receipt of MMD after uptake, and clinical outcomes following transition to MMD in 16 health facilities in Gaza and Inhambane Provinces. This is a secondary analysis involving children <15 years living with HIV with clinical visits during the period from September 2019 to August 2020. Of 4383 children, 82% ever received MMD (at least one pickup of a 3-month MMD supply) during the study period but only 40% received it consistently (defined as MMD at every visit during the study period). Consistent MMD was most common among older children and children without indications of clinical instability. Overall viral load (VL) coverage was 40% (733/1851). Consistent MMD was significantly associated with lower odds of having a VL (0.78, 95% CI: 0.64-0.95). In conclusion, while receipt of a multi-month supply was common particularly during the early days of the COVID-19 pandemic, only a minority of children received consistent MMD; however, there is a need to ensure children with fewer visits still receive timely VL monitoring.
随着儿童接受多月抗逆转录病毒疗法配药(MMD)的情况增加,关于MMD随时间的接受一致性及其与病毒学结果的关联,人们知之甚少。本分析旨在评估加沙和伊尼扬巴内省16个卫生设施中儿童对3个月MMD的接受情况、接受MMD后的持续接受情况以及转为MMD后的临床结果。这是一项二次分析,涉及2019年9月至2020年8月期间接受临床诊治的15岁以下感染艾滋病毒儿童。在4383名儿童中,82%在研究期间曾接受过MMD(至少领取过一次3个月的MMD供应量),但只有40%持续接受(定义为在研究期间每次就诊时都接受MMD)。持续接受MMD在年龄较大的儿童和无临床不稳定迹象的儿童中最为常见。总体病毒载量(VL)检测率为40%(733/1851)。持续接受MMD与较低的VL几率显著相关(0.78,95%置信区间:0.64 - 0.95)。总之,虽然领取多月供应量很常见,尤其是在新冠疫情初期,但只有少数儿童持续接受MMD;然而,有必要确保就诊次数较少的儿童仍能及时接受VL监测。