Ya'an Hospital of Traditional Chinese Medicine, Orthopaedic Clinic, Sichuan, China.
Medicine (Baltimore). 2024 Jul 26;103(30):e39132. doi: 10.1097/MD.0000000000039132.
To investigate the causal relationship between rheumatoid arthritis (RA) and ankylosing spondylitis using Mendelian randomization (MR). Genetic loci independently associated with RA and ankylosing spondylitis in people of European origin were selected as instrumental variables using pooled data from large-scale genome-wide association studies. Three MR analyses, MR-Egger, weighted median, and inverse variance weighting, were used to investigate the causal relationship between RA and ankylosing spondylitis. Heterogeneity and multiplicity tests were used, and a sensitivity test using the "leave-one-out" method was used to explore the robustness of the results. The inverse variance weighting results showed an OR (95 % CI) of 1.25 (1.11-1.41), P < .001, indicating a causal relationship between RA and ankylosing spondylitis. And no heterogeneity and pleiotropy were found by the test and sensitivity analysis also showed robust results. The present study was conducted to analyze and explore the genetic data using two-sample MR analysis and the results showed that there is a causal relationship between RA and the occurrence of ankylosing spondylitis.
采用孟德尔随机化（MR）方法研究类风湿关节炎（RA）和强直性脊柱炎之间的因果关系。从大型全基因组关联研究的汇总数据中选择与欧洲人群 RA 和强直性脊柱炎独立相关的遗传位点作为工具变量。使用 MR-Egger、加权中位数和逆方差加权三种 MR 分析方法来研究 RA 和强直性脊柱炎之间的因果关系。使用异质性和多重性检验，以及使用“逐一剔除”方法的敏感性检验来探索结果的稳健性。逆方差加权结果显示 OR（95%CI）为 1.25（1.11-1.41），P<.001，表明 RA 和强直性脊柱炎之间存在因果关系。且通过检验未发现异质性和多效性，敏感性分析也显示出稳健的结果。本研究通过两样本 MR 分析对遗传数据进行了分析和探讨，结果表明 RA 和强直性脊柱炎的发生之间存在因果关系。
