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海绵窦内颈动脉伴发迅速增大的动脉瘤及海绵窦血栓形成:病例报告及文献复习。

Concomitant rapidly growing aneurysm of intracavernous carotid artery and cavernous sinus thrombosis: Case report and review of the literature.

机构信息

Department of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Province, China.

Department of Neurology, Xiangya Hospital, Central South University, Jiangxi, National Regional Center for Neurological Diseases, Nanchang, Jiangxi Province, China.

出版信息

Medicine (Baltimore). 2024 Jul 26;103(30):e39022. doi: 10.1097/MD.0000000000039022.

Abstract

RATIONALE

Intracavernous infectious aneurysm (ICIA), represents a rare entity that is always described in the form of case reports in the literature. The coexistence of ICIA and cavernous sinus thrombosis (CST) is extremely rare and poorly understood.

PATIENT CONCERNS

A 53-year-old female patient presented to our hospital with headache, nausea and fatigue for 3 weeks. She complained of blurry vision and drooping eyelids before admission. Neurological examination revealed bilateral decreased visual acuity, limitation of extraocular movements and decreased sensation of forehead. Brain magnetic resonance imaging (MRI) showed mixed signal intensities in both cavernous sinuses and expansion of right superior ophthalmic vein, suggesting the formation of CST. One month later, computed tomography angiography (CTA) confirmed a large aneurysm was attached to the left intracavernous carotid artery (ICCA).

DIAGNOESE

This patient was diagnosed with ICIA and CST.

INTERVENTIONS

She was administered with intravenous meropenem and vancomycin and subcutaneous injection of low molecular heparin for 4 weeks.

OUTCOMES

One month later, her extraocular movement had significantly improved, without ptosis and conjunctival congestion. At 1-year follow-up, her ophthalmoplegia fully recovered. Fortunately, such large aneurysm did not rupture in spite of slight broadening.

LESSONS

The coexistence of ICIA and CST is extremely rare. Contiguous infection from adjacent tissues is the foremost cause of ICIA. A repeated angiographic examination is recommended under enough anti-infective treatment due to the characteristics of rapid emergence and fast growth of infectious aneurysms.

摘要

背景

海绵窦内感染性动脉瘤(ICIA)是一种罕见的疾病,其在文献中通常以病例报告的形式描述。ICIA 合并海绵窦血栓形成(CST)的情况极其罕见,目前人们对其了解甚少。

病例介绍

一名 53 岁女性患者因头痛、恶心和疲劳 3 周来我院就诊。入院前,她主诉视力模糊和眼睑下垂。神经科检查显示双侧视力下降、眼球运动受限和额部感觉减退。脑部磁共振成像(MRI)显示双侧海绵窦内混合信号强度和右侧眼上静脉扩张,提示 CST 形成。1 个月后,计算机断层血管造影(CTA)证实左侧海绵内颈内动脉(ICCA)附着一个大动脉瘤。

诊断

该患者被诊断为 ICIA 和 CST。

治疗

给予患者静脉注射美罗培南和万古霉素以及皮下注射低分子肝素 4 周。

结果

1 个月后,患者的眼球运动明显改善,无眼睑下垂和结膜充血。1 年随访时,患者的眼肌麻痹完全恢复。幸运的是,尽管动脉瘤稍有增宽,但未发生破裂。

结论

ICIA 合并 CST 极为罕见。邻近组织的连续感染是导致 ICIA 的首要原因。鉴于感染性动脉瘤的快速出现和快速生长的特点,建议在充分抗感染治疗后进行重复血管造影检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb90/11272256/1d43ba54b238/medi-103-e39022-g001.jpg

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