Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Bioessays. 2024 Oct;46(10):e2400138. doi: 10.1002/bies.202400138. Epub 2024 Jul 26.
Pioneer transcription factors, by virtue of their ability to target nucleosomal DNA in silent chromatin, play crucial roles in eliciting cell fate decisions during development and cellular reprogramming. In addition to their well-established role in chromatin opening to activate gene expression programs, recent studies have demonstrated that pioneer factors have the complementary function of being able to silence the starting cell identity through targeted chromatin repression. Given recent discoveries regarding the repressive aspect of pioneer function, we discuss the basis by which pioneer factors can suppress alternative lineage programs in the context of cell fate control.
先驱转录因子凭借其在沉默染色质中靶向核小体 DNA 的能力，在发育和细胞重编程过程中诱导细胞命运决定方面发挥着关键作用。除了在打开染色质以激活基因表达程序方面的既定作用外，最近的研究还表明，先驱因子具有通过靶向染色质抑制来沉默起始细胞身份的互补功能。鉴于最近关于先驱功能的抑制方面的发现，我们将讨论先驱因子如何在细胞命运控制的背景下抑制替代谱系程序的基础。
