Wang Han, Zhang Duo, Bolm Carsten
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
Angew Chem Int Ed Engl. 2018 May 14;57(20):5863-5866. doi: 10.1002/anie.201801660. Epub 2018 Apr 16.
An efficient photocatalytic functionalization of compounds with benzylic C-H bonds by sulfoximidation in visible light is described. The mild reaction conditions allow the use of a broad array of substrates, including diarylmethane, alkyl arenes, arylacetonitrile, 2-arylacetate, and alkynyl aryl methanes. The sulfoximidation process is highly chemoselective and leads to the corresponding sulfoximines in generally good yields. Mechanistic investigations suggested the intermediacy of sulfoximidoyl radicals.
本文描述了一种在可见光下通过亚磺酰亚胺化实现苄基碳氢键化合物高效光催化官能化的方法。温和的反应条件允许使用多种底物，包括二芳基甲烷、烷基芳烃、芳基乙腈、2-芳基乙酸酯和炔基芳基甲烷。亚磺酰亚胺化过程具有高度的化学选择性，通常能以良好的产率得到相应的亚磺酰亚胺。机理研究表明存在亚磺酰亚胺基自由基中间体。
