Adachi Mental Clinic, Sapporo, Japan.
Musashino Kokubunji Clinic, Tokyo, Japan.
Epilepsy Behav. 2024 Sep;158:109956. doi: 10.1016/j.yebeh.2024.109956. Epub 2024 Jul 25.
The clinical course of interictal psychosis (IIP) has not yet been investigated. We aimed to compared the psychopathology and time-relevant indices between chronic IIP (CIIP) and schizophrenia (SC) METHODS: In this comprehensive psychopathological study, patients with chronic psychosis with and without epilepsy (127 with CIIP and 187 with SC) were compared. Psychopathology was measured using the Brief Psychiatric Rating Scale (BPRS): total, negative symptoms (NSs), positive symptoms (PSs), and anxiety-depressive symptoms (ADSs). Time-relevant indices included age at the time of evaluation, age at the onset of psychosis, and duration of psychosis. The psychopathology of psychosis types and time-relevant indices were analyzed using Pearson's correlation coefficient analysis of covariance.
Age at the time of evaluation was significantly correlated with NS, and ADS scores. Age-relevant trajectories significantly interacted with psychosis types. As age advanced, patients with SC exhibited increased scores, whereas patients with CIIP often exhibited decreased (or unchanged) scores. Age at onset of psychosis was significantly correlated with NS and ADS outcomes in patients with CIIP, whereas it was not correlated in patients with SC. There were significant interactions between age at onset and psychosis types. Patients with early-onset CIIP exhibited higher NS and lower ADS scores, whereas patients with SC exhibited no particular trajectory. The duration of psychosis significantly interacted with the psychosis types in the BPRS total, NSs and PSs. As duration increased, patients with CIIP exhibited no significant relationship, whereas patients with SC exhibited significantly higher psychotic scores.
Psychopathological courses differ between patients with CIIP and SC. Although patients with SC often exhibit deteriorations in psychotic symptoms, patients with CIIP exhibit no distinct deterioration. These findings can contribute psychiatric nosology, treatment strategies, and prediction outcomes.
间歇性精神病（IIP）的临床病程尚未得到研究。我们旨在比较慢性 IIP（CIIP）和精神分裂症（SC）的精神病学和与时间相关的指标。
在这项全面的精神病学研究中，比较了患有慢性精神病合并和不合并癫痫的患者（127 例 CIIP 和 187 例 SC）。精神病学采用简明精神病评定量表（BPRS）进行测量：总分、阴性症状（NSs）、阳性症状（PSs）和焦虑抑郁症状（ADSs）。与时间相关的指标包括评估时的年龄、精神病发病年龄和精神病持续时间。采用皮尔逊相关系数协方差分析分析精神病类型和与时间相关的指标的精神病学。
评估时的年龄与 NS 和 ADS 评分显著相关。年龄相关轨迹与精神病类型显著相互作用。随着年龄的增长，SC 患者的评分增加，而 CIIP 患者的评分往往减少（或不变）。精神病发病年龄与 CIIP 患者的 NS 和 ADS 结果显著相关，而在 SC 患者中则不相关。发病年龄与精神病类型之间存在显著的相互作用。早发性 CIIP 患者的 NS 较高，ADS 评分较低，而 SC 患者则没有特定的轨迹。精神病持续时间与 BPRS 总分、NSs 和 PSs 与精神病类型显著相互作用。随着持续时间的增加，CIIP 患者没有显著的关系，而 SC 患者的精神病评分则显著升高。
CIIP 和 SC 患者的精神病学病程不同。尽管 SC 患者的精神病症状往往恶化，但 CIIP 患者没有明显的恶化。这些发现可以为精神科分类学、治疗策略和预测结果做出贡献。
