Blue Christian M, Wong Stephanie J, Dodson Kelley
Virginia Commonwealth University, School of Medicine, 1201 E Marshall St #4-100, Richmond, VA 23298, USA.
Mount Sinai Kravis Children's Hospital, Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, 234 E 85th St 4th floor, New York, NY 10028, USA.
Am J Otolaryngol. 2024 Sep-Oct;45(5):104417. doi: 10.1016/j.amjoto.2024.104417. Epub 2024 Jul 20.
Evaluate pediatric auditory brainstem response (ABR) findings in children with Autism Spectrum Disorder (ASD) after the 2013 DSM-5 update.
This was an IRB-approved, six-year retrospective chart review evaluating ABR results from pediatric patients with speech delay. Diagnosis of ASD and other neurodevelopmental abnormalities were collected for patient stratification.
From 2017 to 2023, 148 pediatric patients with speech delay were identified through diagnosis of speech delay and underwent ABR testing. Patients were then separated into two groups: Neurotypical (N = 79) and ASD (N = 69). ABR results were obtained through chart review and waveform and interpeak latency (IPL) results were recorded. Differences in waveform and IPL results were determined via Pearson's chi-square test, with multivariate analysis accounting for race, sex, and age.
28 patients with ASD (40.6 %) had at least one waveform/IPL prolongation. Analysis showed an increased incidence of waveform III (p = 0.028) and IPL III-V (p = 0.03) prolongation in the ASD group compared to their neurotypical counterparts. Waveform III prolongation was noted more in females with ASD (p = 0.001) than in males. No statistically significant difference when comparing race and age was found, except in the 2-3 age range (p = 0.003).
There were higher percentages of prolongation for all waveforms and IPLs in the ASD group versus neurotypical, though not as high as previously reported. Race and age did not appear to be factors in ABR findings though more data is needed to make clinical associations.
评估2013年《精神疾病诊断与统计手册》第五版（DSM-5）更新后自闭症谱系障碍（ASD）儿童的小儿听觉脑干反应（ABR）结果。
这是一项经机构审查委员会（IRB）批准的为期六年的回顾性图表审查，评估言语发育迟缓小儿患者的ABR结果。收集ASD和其他神经发育异常的诊断结果用于患者分层。
2017年至2023年期间，通过言语发育迟缓诊断确定了148例言语发育迟缓的小儿患者，并对其进行了ABR测试。然后将患者分为两组：神经典型组（N = 79）和ASD组（N = 69）。通过图表审查获得ABR结果，并记录波形和峰间潜伏期（IPL）结果。波形和IPL结果的差异通过Pearson卡方检验确定，多变量分析考虑了种族、性别和年龄。
28例ASD患者（40.6%）至少有一次波形/IPL延长。分析显示，与神经典型组相比，ASD组中波形III（p = 0.028）和IPL III-V（p = 0.03）延长的发生率更高。ASD女性患者中波形III延长比男性更常见（p = 0.001）。除了2至3岁年龄范围外（p = 0.003），比较种族和年龄时未发现统计学上的显著差异。
与神经典型组相比，ASD组中所有波形和IPL延长的百分比更高，尽管不如先前报道的高。种族和年龄似乎不是ABR结果的影响因素，不过需要更多数据来建立临床关联。
