Department of Audiology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Department of Otolaryngology and Head and Neck Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Neurol Sci. 2019 Jan;40(1):121-125. doi: 10.1007/s10072-018-3594-9. Epub 2018 Oct 4.
Auditory brainstem response (ABR) provides useful information about the auditory brainstem pathway. However, there is little known about the subcortical speech processing in individuals with autism spectrum disorder (ASD). The aim of the present study was to investigate the subcortical speech processing in children with high functioning ASD. Twenty-eight children with ASD, with a mean age of 14.36 ± 1.86, and 28 typically developing (TD) children, with a mean age of 14.99 ± 1.92, were selected from Rofeydeh Rehabilitation Hospital (Tehran, Iran), and speech ABR (sABR) with a 40 ms synthetic /da/ syllable stimulus was recorded. There was no significant difference between the two groups in terms of age and IQ. Latencies of all waves in sABR and duration of V-A complex were significantly longer in children with ASD than in TD children. It was concluded that patients with ASD have deficits in the temporal neural encoding of speech at the brainstem level. Further studies are needed to generalize this result.
听觉脑干反应（ABR）提供了有关听觉脑干通路的有用信息。然而，对于自闭症谱系障碍（ASD）个体的皮质下言语处理知之甚少。本研究旨在探讨高功能自闭症儿童的皮质下言语处理。从罗费德康复医院（伊朗德黑兰）选择了 28 名 ASD 儿童，平均年龄为 14.36±1.86，28 名正常发育（TD）儿童，平均年龄为 14.99±1.92，并记录了言语听觉脑干反应（sABR），使用 40ms 合成的/da/音节刺激。两组在年龄和智商方面没有显著差异。sABR 中所有波的潜伏期和 V-A 复合体的持续时间在 ASD 儿童中明显长于 TD 儿童。结论是，ASD 患者在脑干水平的言语时间神经编码方面存在缺陷。需要进一步的研究来推广这一结果。
