最后，还是 POT1：磷酸化使人类端粒蛋白 POT1 能够招募富含 C 的链端复制机制。
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery.
机构信息
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Mol Cell. 2024 Jul 25;84(14):2598-2600. doi: 10.1016/j.molcel.2024.06.030.
Abstract
Recently in Cell, Cai et al. reported how phosphorylation of human shelterin protein POT1 allows it to recruit the telomeric C-rich strand replication machinery, providing mechanistic insights into an understudied area of telomere biology with implications for telomere biology disorders.
摘要
最近，在《细胞》杂志上，蔡等人报告了人类庇护蛋白 POT1 的磷酸化如何使其能够招募端粒的 C 丰富链复制机制，为端粒生物学中一个研究不足的领域提供了机制上的见解，这对端粒生物学紊乱具有重要意义。
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At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery.最后，还是 POT1：磷酸化使人类端粒蛋白 POT1 能够招募富含 C 的链端复制机制。
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本文引用的文献
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POT1 recruits and regulates CST-Polα/primase at human telomeres.POT1 在人类端粒处招募并调节 CST-Polα/引发酶。
Cell. 2024 Jul 11;187(14):3638-3651.e18. doi: 10.1016/j.cell.2024.05.002. Epub 2024 Jun 4.
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Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.人类 POT1 通过封闭染色体的 5' 端来保护端粒双链 - 单链 DNA 连接点。
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Structures of the human CST-Polα-primase complex bound to telomere templates.人 CST-Polα-引发酶复合物与端粒模板结合的结构。
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Cryo-EM structure of the human CST-Polα/primase complex in a recruitment state.冷冻电镜结构解析人类 CST-Polα/引发酶复合物在募集状态下的结构。
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Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres.POT1 蛋白的不同功能有助于调节端粒酶向端粒的招募。
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The structure of human CST reveals a decameric assembly bound to telomeric DNA.人类 CST 的结构揭示了一个结合在端粒 DNA 上的十聚体组装体。
Science. 2020 Jun 5;368(6495):1081-1085. doi: 10.1126/science.aaz9649.
7
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.端粒 3'突出端来源于 Exo1 和 Apollo 的酶切，并用 POT1b 相关的 CST 进行填补。
Cell. 2012 Jul 6;150(1):39-52. doi: 10.1016/j.cell.2012.05.026. Epub 2012 Jun 28.
8
OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation.含OB折叠结构域蛋白1（OBFC1）是酵母Stn1的人类同源物，与TPP1相关联，并参与端粒长度调控。
J Biol Chem. 2009 Sep 25;284(39):26725-31. doi: 10.1074/jbc.M109.021105. Epub 2009 Aug 1.
9
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.端粒相关蛋白1是纤毛虫端粒酶结合蛋白β的同源物，可与端粒保护蛋白1相互作用以募集端粒酶。
Nature. 2007 Feb 1;445(7127):559-62. doi: 10.1038/nature05469. Epub 2007 Jan 21.
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Science. 2001 May 11;292(5519):1171-5. doi: 10.1126/science.1060036.
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