Thrombosis and Healthy Aging Research Center, Medical Technology School, Faculty of Health Sciences, Interuniversity Center for Healthy Aging, Universidad de Talca, Talca, 3480094, Chile.
CIBER de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Avda. Monforte de Lemos, 28029, Madrid, Madrid, Spain; Geriatrics Department, Hospital Universitario de Getafe, Ctra. Madrid-Toledo km. 12.5, 28905, Getafe, Madrid, Spain.
Free Radic Biol Med. 2024 Oct;223:160-171. doi: 10.1016/j.freeradbiomed.2024.07.022. Epub 2024 Jul 24.
This study explores the physiological changes associated with aging that lead to frailty syndrome, characterized by reduced vitality and degeneration across multiple bodily systems, increasing susceptibility to various pathologies. While established scales like the Fried Phenotype and Frailty Trait Scale (FTS) are commonly used for assessing frailty, incorporating biomarkers is crucial for accurate diagnosis and prognosis. Our research examines plasma oxylipin levels in frail elderly individuals to identify novel biomarkers. Diagnostic criteria for frailty included assessments using the Fried Phenotype and FTS-5, with blood samples collected from 71 elderly participants (50 women and 21 men) with mean ages of 73.6 ± 5.9 and 76.2 ± 6.2 years, respectively. Women exhibited elevated platelet counts (p-value 0.0035). The significant differences in oxylipin concentrations associated with the Fried Phenotype were particularly noteworthy, predominantly observed in women. Specifically, in women, decreased grip strength (<15 kg) and slow gait speed (<0.8 m/s) correlated with increased levels of thromboxane B (TxB) and 7-HDoHE (p-values 0.0404, 0.0300, 0.0033, and 0.0033, respectively). Additionally, elevated 7-HDoHE levels correlated with a BMI exceeding 28 kg/m (p-value 0.0123) and Physical Activity Scale for the Elderly (PASE) scores surpassing 5 points (p-value 0.0134) in women. In summary, our findings emphasize that frail older individuals, particularly women, exhibit higher levels of TxB and 7-HDoHE compared to their non-frail counterparts, aligning with established frailty classification and scale parameters, suggesting their potential as indicative biomarkers.
本研究探讨了与衰老相关的生理变化，这些变化导致衰弱综合征，表现为多个身体系统的活力和功能下降，增加了对各种病理的易感性。虽然 Fried 表型和衰弱特征量表（FTS）等既定量表常用于评估衰弱，但纳入生物标志物对于准确诊断和预后至关重要。我们的研究检查了虚弱老年人的血浆氧化脂水平，以确定新的生物标志物。衰弱的诊断标准包括使用 Fried 表型和 FTS-5 进行评估，从 71 名年龄在 73.6±5.9 岁至 76.2±6.2 岁的老年参与者（50 名女性和 21 名男性）中采集血液样本。女性的血小板计数升高（p 值 0.0035）。与 Fried 表型相关的氧化脂浓度的显著差异特别值得注意，主要在女性中观察到。具体而言，在女性中，握力下降（<15kg）和步态速度缓慢（<0.8m/s）与血栓素 B（TxB）和 7-HDoHE 水平升高相关（p 值分别为 0.0404、0.0300、0.0033 和 0.0033）。此外，7-HDoHE 水平升高与 BMI 超过 28kg/m（p 值 0.0123）和老年人体力活动量表（PASE）评分超过 5 分（p 值 0.0134）相关。综上所述，我们的研究结果强调，与非衰弱者相比，虚弱的老年个体，尤其是女性，表现出更高的 TxB 和 7-HDoHE 水平，与既定的衰弱分类和量表参数一致，表明它们作为生物标志物的潜在价值。
