German Center for Diabetes Research (DZD), Partner Düsseldorf, 85764, München-Neuherberg, Germany; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Free Radic Biol Med. 2024 Oct;223:87-95. doi: 10.1016/j.freeradbiomed.2024.07.028. Epub 2024 Jul 24.
Oxidative stress is a risk factor for distal sensorimotor polyneuropathy (DSPN). Selenoprotein P is a protein with antioxidant properties but has not been investigated in the context of DSPN. This study aimed to assess the associations between selenoprotein P and DSPN in people without and with type 2 diabetes (T2D).
Cross-sectional and prospective analyses were based on 1053 (including 217 with T2D) and 513 participants (including 79 with T2D), respectively, aged 61-82 years from the population-based KORA F4 survey. DSPN at baseline (KORA F4) and in the follow-up survey KORA FF4 was defined based on the Michigan Neuropathy Screening Instrument. Serum levels of full-length selenoprotein P were quantified by ELISA. Associations between selenoprotein P and prevalent or incident DSPN were estimated using logistic regression analysis adjusting for multiple confounders.
Selenoprotein P levels were not associated with prevalent DSPN in the total sample. However, there was a significant interaction by diabetes status. Higher levels of selenoprotein P were associated with lower odds of prevalent DSPN in individuals without T2D (fully adjusted model: OR 0.825 [95 % CI 0.682, 0.998], p = 0.0476), but not in those with T2D (OR [95 % CI] 1.098 [0.829, 1.454], p = 0.5132; p = 0.0488). Selenoprotein P levels were not associated with incident DSPN over a follow-up of 6.5 years.
In individuals without T2D from the older general population, lower selenoprotein P levels were associated with a higher prevalence of DSPN. Whether the antioxidant properties of selenoprotein P are responsible for the observed associations remains to be elucidated in future research.
氧化应激是远端感觉运动多发性神经病（DSPN）的一个危险因素。硒蛋白 P 是一种具有抗氧化特性的蛋白质，但尚未在 DSPN 中进行研究。本研究旨在评估硒蛋白 P 与无 2 型糖尿病（T2D）和有 2 型糖尿病（T2D）人群中 DSPN 的相关性。
基于来自基于人群的 KORA F4 调查的 1053 名（包括 217 名患有 T2D）和 513 名参与者（包括 79 名患有 T2D）的横断面和前瞻性分析，参与者年龄为 61-82 岁。根据密歇根神经病变筛查工具，在基线（KORA F4）和随访调查 KORA FF4 中定义 DSPN。通过 ELISA 定量测定全长硒蛋白 P 的血清水平。使用逻辑回归分析调整多种混杂因素后，估计硒蛋白 P 与现患或新发 DSPN 之间的相关性。
硒蛋白 P 水平与总样本中的现患 DSPN 无关。然而，按糖尿病状态存在显著的交互作用。在无 T2D 个体中，较高的硒蛋白 P 水平与现患 DSPN 的较低几率相关（完全调整模型：OR 0.825 [95%CI 0.682,0.998]，p=0.0476），但在有 T2D 个体中无相关性（OR [95%CI] 1.098 [0.829,1.454]，p=0.5132；p=0.0488）。在随访 6.5 年后，硒蛋白 P 水平与新发 DSPN 无关。
在来自年龄较大的普通人群中无 T2D 的个体中，较低的硒蛋白 P 水平与 DSPN 的更高患病率相关。硒蛋白 P 的抗氧化特性是否导致观察到的相关性仍有待未来研究阐明。
