Chen Hsiao-Fan, Wu Kou-Juey
Graduate Institutes of Biomedical Sciences, China Medical University, Taichung, Taiwan; Graduate Institutes of Cell Biology, China Medical University, Taichung, Taiwan.
Cancer Genome Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Biomed J. 2024 Jul 25;48(2):100774. doi: 10.1016/j.bj.2024.100774.
Asymmetric cell division (ACD) plays a pivotal role in development, tissue homeostasis, and stem cell maintenance. Emerging evidence suggests that long non-coding RNAs (lncRNAs) are key regulators of ACD, orchestrating the intricate molecular machinery that governs cell fate determination. This review summarizes current literature to elucidate the diverse roles of lncRNAs in modulating ACD across various biological contexts. The regulatory mechanisms of asymmetric cell division mediated by lncRNAs, including their interactions with protein effectors, epigenetic regulation, and subcellular localization are explored. Additionally, we discuss the implications of dysregulated lncRNAs in mediating ACD that lead to tumorigenesis. By integrating findings from diverse experimental models and cell types, this review provides insights into the multifaceted roles of lncRNAs in governing asymmetric cell division, shedding light on fundamental biological processes. Further research in this area may lead to the development of novel therapies targeting dysregulated lncRNAs to restore proper cell division and function. The knowledge of lncRNAs regulating ACD could potentially revolutionize the field of regenerative medicine and cancer therapy by targeting specific lncRNAs involved in ACD. By unraveling the complex interactions between lncRNAs and cellular processes, the potential novel opportunities for precision medicine approaches may be uncovered.
不对称细胞分裂（ACD）在发育、组织稳态和干细胞维持中起着关键作用。新出现的证据表明，长链非编码RNA（lncRNAs）是ACD的关键调节因子，它们协调着控制细胞命运决定的复杂分子机制。本综述总结了当前文献，以阐明lncRNAs在各种生物学背景下调节ACD的不同作用。探讨了lncRNAs介导不对称细胞分裂的调控机制，包括它们与蛋白质效应器的相互作用、表观遗传调控和亚细胞定位。此外，我们还讨论了lncRNAs失调在介导导致肿瘤发生的ACD中的影响。通过整合来自不同实验模型和细胞类型的研究结果，本综述深入探讨了lncRNAs在控制不对称细胞分裂中的多方面作用，为基本生物学过程提供了新的见解。该领域的进一步研究可能会导致开发针对失调lncRNAs的新型疗法，以恢复正常的细胞分裂和功能。了解lncRNAs对ACD的调节作用可能会通过靶向参与ACD的特定lncRNAs，彻底改变再生医学和癌症治疗领域。通过揭示lncRNAs与细胞过程之间的复杂相互作用，可能会发现精准医学方法的潜在新机会。
